HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells
Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric cancer remain unknown. In the present st...
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| Veröffentlicht in: | Gene 2016-08, Vol.587 (1), p.42-47 |
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| creator | Chushi, Li Wei, Wu Kangkang, Xie Yongzeng, Feng Ning, Xie Xiaolei, Chen |
| description | Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric cancer remain unknown. In the present study, we investigated the expression profile and the biological functions of HMGCR in gastric cancer. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells. In the further molecular mechanism study, HMGCR was shown to activate Hedgehog/Gli1 signaling and promoted the expression of Gli1 target genes. Taken together, this study demonstrated the tumor-promoting effects of HMGCR in gastric cancer and suggested HMGCR as a promising therapeutic target.
•HMGCR is overexpressed in GC samples.•HMGCR positively regulates the growth, migration and tumorigenesis of GC cells.•HMGCR activates Hedgehog signaling. |
| doi_str_mv | 10.1016/j.gene.2016.04.029 |
| format | Article |
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•HMGCR is overexpressed in GC samples.•HMGCR positively regulates the growth, migration and tumorigenesis of GC cells.•HMGCR activates Hedgehog signaling.</description><subject>Animals</subject><subject>Carcinogenesis</subject><subject>Cell growth and migration</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Hedgehog/Gli1 signaling</subject><subject>HMGCR</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl CoA Reductases - genetics</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Signal Transduction</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Transcriptome</subject><subject>Up-Regulation</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv3CAUhVHVKpmk-QNdVCy7sXvBxoCUTTRqHlKiSlW7RpiHw2hsTwC36r8Pk5lm2bABXb5zdHUOQp8I1ARI93VTD25yNS3vGtoaqHyHVkRwWQE04j1aQcNFRQiRp-gspQ2Uwxg9QaeUg2CtaFZI3z7crH_gkPCyq6Iblq3OzuIw4UGnHIPBRk_GRawni3dxHufsEs6PDg9x_pMfX-ZjGKLOYZ7w7F_-jhrjttv0EX3wepvcxfE-R7-uv_1c31b332_u1lf3lWkZy5UXvNO8Z5IT8Kyn0nLo-p52jLRMik72vifeUCOt570GJq30sjHWNCBaz5tz9OXgW7Z8WlzKagxpv4Ge3LwkRQSIriGckbdRLqEjHdC2oPSAmjinFJ1XuxhGHf8qAmrfgtqofQtq34KCVpUWiujz0X_pR2dfJf9iL8DlAXAlkN_BRZVMcCUzG6IzWdk5_M__GTXbl9I</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Chushi, Li</creator><creator>Wei, Wu</creator><creator>Kangkang, Xie</creator><creator>Yongzeng, Feng</creator><creator>Ning, Xie</creator><creator>Xiaolei, Chen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20160801</creationdate><title>HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells</title><author>Chushi, Li ; Wei, Wu ; Kangkang, Xie ; Yongzeng, Feng ; Ning, Xie ; Xiaolei, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-f876a7b59710f5b29d706bb2651459869bfb1fc2c9df7ba059d9f93cdc3084f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Carcinogenesis</topic><topic>Cell growth and migration</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hedgehog Proteins - metabolism</topic><topic>Hedgehog/Gli1 signaling</topic><topic>HMGCR</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl CoA Reductases - genetics</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Signal Transduction</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Transcriptome</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chushi, Li</creatorcontrib><creatorcontrib>Wei, Wu</creatorcontrib><creatorcontrib>Kangkang, Xie</creatorcontrib><creatorcontrib>Yongzeng, Feng</creatorcontrib><creatorcontrib>Ning, Xie</creatorcontrib><creatorcontrib>Xiaolei, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chushi, Li</au><au>Wei, Wu</au><au>Kangkang, Xie</au><au>Yongzeng, Feng</au><au>Ning, Xie</au><au>Xiaolei, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>587</volume><issue>1</issue><spage>42</spage><epage>47</epage><pages>42-47</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric cancer remain unknown. In the present study, we investigated the expression profile and the biological functions of HMGCR in gastric cancer. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells. In the further molecular mechanism study, HMGCR was shown to activate Hedgehog/Gli1 signaling and promoted the expression of Gli1 target genes. Taken together, this study demonstrated the tumor-promoting effects of HMGCR in gastric cancer and suggested HMGCR as a promising therapeutic target.
•HMGCR is overexpressed in GC samples.•HMGCR positively regulates the growth, migration and tumorigenesis of GC cells.•HMGCR activates Hedgehog signaling.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27085483</pmid><doi>10.1016/j.gene.2016.04.029</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Carcinogenesis Cell growth and migration Cell Line, Tumor Cell Movement Gastric cancer Gene Expression Regulation, Neoplastic Hedgehog Proteins - metabolism Hedgehog/Gli1 signaling HMGCR Humans Hydroxymethylglutaryl CoA Reductases - genetics Mice Mice, Nude Signal Transduction Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transcriptome Up-Regulation |
| title | HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells |
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