Neisseria meningitis GNA1030 is a ubiquinone‐8 binding protein

ABSTRACT Bexsero, a new vaccine against Neisseria meningitidis serogroup B (MenB), is composed of 3 main recombinant proteins and an outer membrane vesicle component. One of the main bactericidal antigens, neisseria heparin binding antigen (NHBA), is present as a fusion protein with the accessory pr...

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Veröffentlicht in:	The FASEB journal 2015-06, Vol.29 (6), p.2260-2267
Hauptverfasser:	Donnarumma, Danilo, Golfieri, Giacomo, Brier, Sébastien, Castagnini, Marta, Veggi, Daniele, Bottomley, Matthew James, Delany, Isabel, Norais, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - pharmacology Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Antimycin A - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bexsero vaccine Blotting, Western Cell Survival - drug effects Cell Survival - genetics Cloning, Molecular Disulfides - metabolism Electron Transport Complex III - antagonists & inhibitors Electron Transport Complex III - metabolism Hydrogen Peroxide - pharmacology Mass Spectrometry - methods Meningococcal Vaccines - metabolism Methacrylates - pharmacology Molecular Sequence Data Mutation native mass spectrometry Neisseria meningitidis Neisseria meningitidis - genetics Neisseria meningitidis - growth & development Neisseria meningitidis - metabolism NUbp Oxidants - pharmacology Periplasmic Proteins - chemistry Periplasmic Proteins - genetics Periplasmic Proteins - metabolism Protein Binding Protein Multimerization Thiazoles - pharmacology Ubiquinone - metabolism
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