Prenatal Exposure of Cypermethrin Induces Similar Alterations in Xenobiotic-Metabolizing Cytochrome P450s and Rate-Limiting Enzymes of Neurotransmitter Synthesis in Brain Regions of Rat Offsprings During Postnatal Development

Oral administration of low doses of cypermethrin to pregnant Wistar rats led to a dose-dependent differences in the induction of xenobiotic-metabolizing cytochrome P450s (CYPs) messenger RNA (mRNA) and protein in brain regions isolated from the offsprings postnatally at 3 weeks that persisted up to...

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Veröffentlicht in:	Molecular neurobiology 2016-08, Vol.53 (6), p.3670-3689
Hauptverfasser:	Singh, Anshuman, Mudawal, Anubha, Maurya, Pratibha, Jain, Rajeev, Nair, Saumya, Shukla, Rajendra K., Yadav, Sanjay, Singh, Dhirendra, Khanna, Vinay Kumar, Chaturvedi, Rajnish Kumar, Mudiam, Mohana K. R., Sethumadhavan, Rao, Siddiqi, Mohammad Imran, Parmar, Devendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biocatalysis Biomedical and Life Sciences Biomedicine Brain Brain - enzymology Brain - pathology Cell Biology Computer Simulation Cytochrome P-450 Enzyme System - metabolism Enzymes Female Gene Expression Regulation Intercellular Signaling Peptides and Proteins - blood Learning - drug effects Male Metabolome - genetics Molecular Docking Simulation Neurobiology Neurology Neurosciences Neurotransmitter Agents - biosynthesis Neurotransmitters Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - enzymology Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - pathology Pyrethrins - adverse effects Pyrethrins - chemistry Pyrethrins - metabolism Rats, Wistar Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA Spatial Memory - drug effects Structural Homology, Protein Xenobiotics - metabolism
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