HIV-1 transcriptional activity during frequent longitudinal sampling in aviremic patients on antiretroviral therapy

BACKGROUND:HIV-1 transcription during suppressive antiretroviral therapy (ART) is not well understood. This is problematic as latency-reactivating agent-based HIV-1 eradication trials utilize changes in viral transcription as an efficacy biomarker. METHODS:We conducted an observational cohort study...

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Veröffentlicht in:	AIDS (London) 2016-03, Vol.30 (5), p.713-721
Hauptverfasser:	Leth, Steffen, Nymann, Rasmus, Jørgensen, Sofie, Olesen, Rikke, Rasmussen, Thomas Aagaard, Østergaard, Lars, Denton, Paul W, Tolstrup, Martin, Søgaard, Ole Schmeltz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS/HIV Anti-Retroviral Agents - therapeutic use CD4-Positive T-Lymphocytes - virology Clinical Trials as Topic DNA, Viral - analysis DNA, Viral - genetics Female Gene Expression Profiling HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lentivirus Longitudinal Studies Male Middle Aged Prospective Studies Retroviridae RNA, Viral - analysis RNA, Viral - genetics Transcription, Genetic
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