The role of APC/C super(Cdh1) in replication stress and origin of genomic instability

It has been proposed that the APC/C super(Cdh1) functions as a tumor suppressor by maintaining genomic stability. However, the exact nature of genomic instability following loss of Cdh1 is unclear. Using biochemistry and live cell imaging of single cells we found that Cdh1 knockdown (kd) leads to st...

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Veröffentlicht in:	Oncogene 2016-06, Vol.35 (23), p.3062-3070
Hauptverfasser:	Greil, C, Krohs, J, Schnerch, D, Follo, M, Felthaus, J, Engelhardt, M, Waesch, R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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