Bone marrow Th17 TNFα cells induce osteoclast differentiation, and link bone destruction to IBD

ObjectiveUnder both physiological and pathological conditions, bone volume is determined by the rate of bone formation by osteoblasts and bone resorption by osteoclasts. Excessive bone loss is a common complication of human IBD whose mechanisms are not yet completely understood. Despite the role of...

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Veröffentlicht in:	Gut 2015-07, Vol.64 (7), p.1072-1081
Hauptverfasser:	Ciucci, Thomas, Ibáñez, Lidia, Boucoiran, Agathe, Birgy-Barelli, Eléonore, Pène, Jérôme, Abou-Ezzi, Grazia, Arab, Nadia, Rouleau, Matthieu, Hébuterne, Xavier, Yssel, Hans, Blin-Wakkach, Claudine, Wakkach, Abdelilah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - physiology Animals Bone Diseases - immunology Bone Diseases - physiopathology Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - physiology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation Crohn Disease - immunology Crohn Disease - physiopathology Disease Models, Animal Humans Immunohistochemistry Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - physiopathology Interleukin-7 - physiology Mice, Inbred BALB C Mice, Inbred C57BL Osteoclasts - immunology Osteoclasts - physiology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - physiology Th17 Cells - immunology Th17 Cells - physiology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - physiology
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