GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis

Exocytosis of mam maUan sperm dense-core secretory granule relies on the same fusion molecules as all other secretory cells; one such molecule is the small GTPase Rab3A. Here, we report an in-depth biochemical characterization of the role of Rab3A in secretion by scrutinizingthe exocytotic response...

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Veröffentlicht in:	Journal of molecular cell biology 2014-08, Vol.6 (4), p.286-298
Hauptverfasser:	Bustos, Matías A, Roggero, Carlos M, De la Iglesia, Paola X, Mayorga, Luis S, Tomes, Claudia N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome - metabolism Adult Amino Acid Sequence Calcium - metabolism Cell Membrane - metabolism Cytoplasmic Granules - metabolism Exocytosis - physiology Fluorescent Antibody Technique G-蛋白 Guanosine Triphosphate - metabolism Humans Male Membrane Fusion - physiology Molecular Sequence Data rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Rab3a rab3A GTP-Binding Protein - metabolism Receptors, Androgen - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid Spermatozoa - metabolism Young Adult 人类分泌颗粒精子胞吐过程致密核负面作用
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