Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort
We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and...
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| Veröffentlicht in: | American journal of epidemiology 2016-06, Vol.183 (11), p.1008-1017 |
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| creator | Harpsøe, Maria C Nielsen, Nete M Friis-Møller, Nina Andersson, Mikael Wohlfahrt, Jan Linneberg, Allan Nohr, Ellen A Jess, Tine |
| description | We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI |
| doi_str_mv | 10.1093/aje/kwv300 |
| format | Article |
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We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwv300</identifier><identifier>PMID: 27188940</identifier><language>eng</language><publisher>United States: Oxford Publishing Limited (England)</publisher><subject>Acute Disease ; Adult ; Anti-Infective Agents - therapeutic use ; Antimicrobial agents ; Body Height ; Body Mass Index ; Body Weight ; Communicable Diseases - drug therapy ; Communicable Diseases - epidemiology ; Denmark - epidemiology ; Epidemiology ; Female ; Health Behavior ; Hospitalization ; Humans ; Incidence ; Infectious diseases ; Medical treatment ; Obesity - epidemiology ; Overweight - epidemiology ; Proportional Hazards Models ; Prospective Studies ; Respiratory Tract Infections - epidemiology ; Risk Factors ; Skin Diseases, Infectious - epidemiology ; Socioeconomic Factors ; Thinness - epidemiology</subject><ispartof>American journal of epidemiology, 2016-06, Vol.183 (11), p.1008-1017</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Jun 1, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-3d9a79390464b02a55d43ec9b016af028925db16d6c4720cd9654634233caf693</citedby><cites>FETCH-LOGICAL-c384t-3d9a79390464b02a55d43ec9b016af028925db16d6c4720cd9654634233caf693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27188940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harpsøe, Maria C</creatorcontrib><creatorcontrib>Nielsen, Nete M</creatorcontrib><creatorcontrib>Friis-Møller, Nina</creatorcontrib><creatorcontrib>Andersson, Mikael</creatorcontrib><creatorcontrib>Wohlfahrt, Jan</creatorcontrib><creatorcontrib>Linneberg, Allan</creatorcontrib><creatorcontrib>Nohr, Ellen A</creatorcontrib><creatorcontrib>Jess, Tine</creatorcontrib><title>Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antimicrobial agents</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Communicable Diseases - drug therapy</subject><subject>Communicable Diseases - epidemiology</subject><subject>Denmark - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Behavior</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Medical treatment</subject><subject>Obesity - epidemiology</subject><subject>Overweight - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Risk Factors</subject><subject>Skin Diseases, Infectious - epidemiology</subject><subject>Socioeconomic Factors</subject><subject>Thinness - epidemiology</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLw0AQwPFFFFurFz-ALHgRITr7yCZ7bOurUBXExzFsshuTtsnW3UTttzel1YOngeHHMPwROiZwQUCySzUzl_OvTwawg_qERyIQNBS7qA8ANJBU0B468H4GQIgMYR_1aETiWHLoo9eR1St8r7zHk1qbb6xqjZ9KP8c27za5yZrS1h4PK1u_4zdbmRqXNW4Kg69UXfoCP6i1UAs8Kl1T4LEtrGsO0V6uFt4cbecAvdxcP4_vgunj7WQ8nAYZi3kTMC1VJJkELngKVIWh5sxkMgUiVA40ljTUKRFaZDyikGkpQi4Yp4xlKheSDdDZ5u7S2Y_W-CapSp-ZxULVxrY-ITHEXQwqeEdP_9GZbV33eKciKagkIQs7db5RmbPeO5MnS1dWyq0SAsm6dtLVTja1O3yyPdmmldF_9Dcv-wGRlHiZ</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Harpsøe, Maria C</creator><creator>Nielsen, Nete M</creator><creator>Friis-Møller, Nina</creator><creator>Andersson, Mikael</creator><creator>Wohlfahrt, Jan</creator><creator>Linneberg, Allan</creator><creator>Nohr, Ellen A</creator><creator>Jess, Tine</creator><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TS</scope></search><sort><creationdate>20160601</creationdate><title>Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort</title><author>Harpsøe, Maria C ; Nielsen, Nete M ; Friis-Møller, Nina ; Andersson, Mikael ; Wohlfahrt, Jan ; Linneberg, Allan ; Nohr, Ellen A ; Jess, Tine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-3d9a79390464b02a55d43ec9b016af028925db16d6c4720cd9654634233caf693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antimicrobial agents</topic><topic>Body Height</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Communicable Diseases - drug therapy</topic><topic>Communicable Diseases - epidemiology</topic><topic>Denmark - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Behavior</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Medical treatment</topic><topic>Obesity - epidemiology</topic><topic>Overweight - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Risk Factors</topic><topic>Skin Diseases, Infectious - epidemiology</topic><topic>Socioeconomic Factors</topic><topic>Thinness - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harpsøe, Maria C</creatorcontrib><creatorcontrib>Nielsen, Nete M</creatorcontrib><creatorcontrib>Friis-Møller, Nina</creatorcontrib><creatorcontrib>Andersson, Mikael</creatorcontrib><creatorcontrib>Wohlfahrt, Jan</creatorcontrib><creatorcontrib>Linneberg, Allan</creatorcontrib><creatorcontrib>Nohr, Ellen A</creatorcontrib><creatorcontrib>Jess, Tine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Physical Education Index</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harpsøe, Maria C</au><au>Nielsen, Nete M</au><au>Friis-Møller, Nina</au><au>Andersson, Mikael</au><au>Wohlfahrt, Jan</au><au>Linneberg, Allan</au><au>Nohr, Ellen A</au><au>Jess, Tine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>183</volume><issue>11</issue><spage>1008</spage><epage>1017</epage><pages>1008-1017</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><abstract>We investigated the possible association between body mass index (BMI; weight (kg)/height (m)(2)) and hospitalization or treatment for acute infection in a prospective cohort study. We linked 75,001 women enrolled in the Danish National Birth Cohort from 1996 to 2002, who had information on BMI and a broad range of confounders, to data on infectious diseases and use of antimicrobial agents from the National Patient Register and the Danish Prescription Register. Associations were tested using Cox proportional hazards models. During 12 years of follow-up, we observed a U-shaped association between baseline BMI and later hospitalization for 1) any infectious disease and 2) infections of the respiratory tract, whereas a dose-response relationship was seen for skin infections. The most pronounced associations were seen for acute upper respiratory infections at multiple and unspecified sites (underweight (BMI <18.5): hazard ratio (HR) = 4.26, 95% confidence interval (CI): 1.69, 10.7; obesity (BMI ≥30): HR = 3.64, 95% CI: 1.62, 8.18), erysipelas (obesity: HR = 5.19, 95% CI: 3.38, 7.95), and fungal infections (underweight: HR = 3.19, 95% CI: 1.53, 6.66). Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30; HR = 1.08, 95% CI: 1.06, 1.10) and obese (HR = 1.21, 95% CI: 1.17, 1.24) women. Among Danish women, underweight and obesity were associated with increased risk of community-acquired infectious diseases, especially infections of the upper respiratory tract and skin.</abstract><cop>United States</cop><pub>Oxford Publishing Limited (England)</pub><pmid>27188940</pmid><doi>10.1093/aje/kwv300</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acute Disease Adult Anti-Infective Agents - therapeutic use Antimicrobial agents Body Height Body Mass Index Body Weight Communicable Diseases - drug therapy Communicable Diseases - epidemiology Denmark - epidemiology Epidemiology Female Health Behavior Hospitalization Humans Incidence Infectious diseases Medical treatment Obesity - epidemiology Overweight - epidemiology Proportional Hazards Models Prospective Studies Respiratory Tract Infections - epidemiology Risk Factors Skin Diseases, Infectious - epidemiology Socioeconomic Factors Thinness - epidemiology |
| title | Body Mass Index and Risk of Infections Among Women in the Danish National Birth Cohort |
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