Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum

[Display omitted] In this report, we describe the synthesis of 1-(Phthalazin-4-yl)-hydrazine using bronsted acidic ionic liquids and demonstrate their ability to inhibit asexual stage development of human malaria parasite, Plasmodium falciparum. Through computational studies, we short-listed chemica...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-07, Vol.26 (14), p.3300-3306
Hauptverfasser:	Subramanian, Gowtham, Babu Rajeev, C.P., Mohan, Chakrabhavi Dhananjaya, Sinha, Ameya, Chu, Trang T.T., Anusha, Sebastian, Ximei, Huang, Fuchs, Julian E., Bender, Andreas, Rangappa, Kanchugarakoppal S., Chandramohanadas, Rajesh, Basappa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Bronsted acidic ionic liquids Cell Line Dihydroorotate dehydrogenase Dogs Dose-Response Relationship, Drug Hydralazines Molecular Structure P. falciparum Parasitic Sensitivity Tests Phthalazines - chemical synthesis Phthalazines - chemistry Phthalazines - pharmacology Plasmodium falciparum Plasmodium falciparum - drug effects Structure-Activity Relationship
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