Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning

•HBO-PC reduced infarct volume ratio and neurobehavioral deficit in MCAO rats.•It also increased the expression of Sirt1 and Nrf2/antioxidant defense pathway.•The neuroprotective effects of HBO-PC were inhibited by Sirt1 or Nrf2 siRNA.•Sirt1 siRNA inhibited Nrf2 expression, but Nrf2 siRNA had no eff...

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Veröffentlicht in:	Behavioural brain research 2016-08, Vol.309, p.1-8
Hauptverfasser:	Xue, Fen, Huang, Jin-wen, Ding, Pei-yan, Zang, Hong-gang, Kou, Zhi-jian, Li, Ting, Fan, Juan, Peng, Zheng-wu, Yan, Wen-jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Brain - blood supply Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy Disease Models, Animal HBO-PC Heme Oxygenase-1 - metabolism Hyperbaric Oxygenation Ischemic Preconditioning Malondialdehyde - metabolism MCAO Neuroprotection NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative stress Oxidative Stress - physiology Random Allocation Rats, Sprague-Dawley RNA, Small Interfering Signal Transduction Sirt1 Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - genetics Sirtuin 1 - metabolism Superoxide Dismutase-1 - metabolism
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