Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns
Animal and human studies have suggested that phthalate alters thyroid hormone concentrations. This study investigated the associations between phthalate exposure during the first trimester and thyroid hormones in pregnant women and their newborns. Pregnant women were enrolled from the prospective Ma...
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| Veröffentlicht in: | Chemosphere (Oxford) 2016-08, Vol.157, p.42-48 |
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| creator | Yao, Hui-yuan Han, Yan Gao, Hui Huang, Kun Ge, Xing Xu, Yuan-yuan Xu, Ye-qing Jin, Zhong-xiu Sheng, Jie Yan, Shuang-qin Zhu, Peng Hao, Jia-hu Tao, Fang-biao |
| description | Animal and human studies have suggested that phthalate alters thyroid hormone concentrations. This study investigated the associations between phthalate exposure during the first trimester and thyroid hormones in pregnant women and their newborns. Pregnant women were enrolled from the prospective Ma’anshan Birth Cohort study in China. A standard questionnaire was completed by the women at the first antenatal visit. Seven phthalate metabolites were measured in one-spot urine at enrolment (10.0 ± 2.1 gestational weeks), as were thyroid hormone levels in maternal and cord sera. Multivariable linear regression showed that 1-standard deviation (SD) increase in natural log (ln)-transformed mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was associated with 0.163 μg/dL (p = 0.001) and 0.173 μg/dL (p = 0.001) decreases in maternal total thyroxine (TT4). Both MEHP and MEHHP were negatively associated with maternal free thyroxine (FT4; β: −0.013, p |
| doi_str_mv | 10.1016/j.chemosphere.2016.05.023 |
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•We assessed seven phthalate metabolites level of urine samples in pregnancy women.•We measured thyroid hormone (TH) concentrations in maternal and cord serum.•The study had a prospective design and large sample size.•It is the largest study examing THs change on phthalates exposure in pregnancy.•Phthalates exposure during the first trimester may disrupt maternal THs levels.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2016.05.023</identifier><identifier>PMID: 27208644</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Biotransformation ; China ; Diethylhexyl Phthalate - urine ; Endocrine disruption ; Female ; Humans ; Infant, Newborn ; Maternal Exposure ; Newborn ; Phthalate ; Phthalic Acids - metabolism ; Phthalic Acids - pharmacology ; Phthalic Acids - urine ; Pregnancy ; Pregnancy Trimester, First - metabolism ; Pregnancy women ; Prospective Studies ; Thyroid hormone ; Thyroid Hormones - blood ; Thyrotropin - blood ; Thyroxine - blood ; Urinary metabolites</subject><ispartof>Chemosphere (Oxford), 2016-08, Vol.157, p.42-48</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-bb868ab15c6a10d5ba00bdde75ea2c35cbb03c6af2608ea9c1f0bb0f76a478ce3</citedby><cites>FETCH-LOGICAL-c410t-bb868ab15c6a10d5ba00bdde75ea2c35cbb03c6af2608ea9c1f0bb0f76a478ce3</cites><orcidid>0000-0001-5179-0805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2016.05.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27208644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Hui-yuan</creatorcontrib><creatorcontrib>Han, Yan</creatorcontrib><creatorcontrib>Gao, Hui</creatorcontrib><creatorcontrib>Huang, Kun</creatorcontrib><creatorcontrib>Ge, Xing</creatorcontrib><creatorcontrib>Xu, Yuan-yuan</creatorcontrib><creatorcontrib>Xu, Ye-qing</creatorcontrib><creatorcontrib>Jin, Zhong-xiu</creatorcontrib><creatorcontrib>Sheng, Jie</creatorcontrib><creatorcontrib>Yan, Shuang-qin</creatorcontrib><creatorcontrib>Zhu, Peng</creatorcontrib><creatorcontrib>Hao, Jia-hu</creatorcontrib><creatorcontrib>Tao, Fang-biao</creatorcontrib><title>Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Animal and human studies have suggested that phthalate alters thyroid hormone concentrations. This study investigated the associations between phthalate exposure during the first trimester and thyroid hormones in pregnant women and their newborns. Pregnant women were enrolled from the prospective Ma’anshan Birth Cohort study in China. A standard questionnaire was completed by the women at the first antenatal visit. Seven phthalate metabolites were measured in one-spot urine at enrolment (10.0 ± 2.1 gestational weeks), as were thyroid hormone levels in maternal and cord sera. Multivariable linear regression showed that 1-standard deviation (SD) increase in natural log (ln)-transformed mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was associated with 0.163 μg/dL (p = 0.001) and 0.173 μg/dL (p = 0.001) decreases in maternal total thyroxine (TT4). Both MEHP and MEHHP were negatively associated with maternal free thyroxine (FT4; β: −0.013, p < 0.001 and β: −0.011, p = 0.001, respectively) and positively associated with maternal thyroid-stimulating hormone (β: 0.101, p < 0.001; β: 0.132, p < 0.001, respectively). An inverse association was observed between monobenzyl phthalate and maternal TT4 and FT4. A 1-SD increase in ln-transformed monoethyl phthalate was inversely associated with maternal TT4 (β: −0.151, p = 0.002). By contrast, the concentrations of phthalate metabolites in urine were not associated with those of thyroid hormone in cord serum. Our analysis suggested that phthalate exposure during the first trimester disrupts maternal thyroid hormone levels.
•We assessed seven phthalate metabolites level of urine samples in pregnancy women.•We measured thyroid hormone (TH) concentrations in maternal and cord serum.•The study had a prospective design and large sample size.•It is the largest study examing THs change on phthalates exposure in pregnancy.•Phthalates exposure during the first trimester may disrupt maternal THs levels.</description><subject>Adult</subject><subject>Biotransformation</subject><subject>China</subject><subject>Diethylhexyl Phthalate - urine</subject><subject>Endocrine disruption</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal Exposure</subject><subject>Newborn</subject><subject>Phthalate</subject><subject>Phthalic Acids - metabolism</subject><subject>Phthalic Acids - pharmacology</subject><subject>Phthalic Acids - urine</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - metabolism</subject><subject>Pregnancy women</subject><subject>Prospective Studies</subject><subject>Thyroid hormone</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Urinary metabolites</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQhS0EopfCX0BmxybBTuLEXqIrXlIRG1hbfkwaXyV2GCct_fe43ILYwcryzHdmRucQ8oqzmjPevznVboIl5XUChLoppZqJmjXtI3LgclAVb5R8TA6MdaLqRSsuyLOcT4wVUqin5KIZGib7rjuQm89mA4xmpuu0TWYuPwo_1pR3BOp3DPGabhPQMWDe6IZhgVwE1ERPM-C-lO4dpuDplHBJETINka4I19HEjd6mBeIvuAwJSCPc2oQxPydPRjNnePHwXpJv7999PX6srr58-HR8e1W5jrOtslb20lguXG8488Iaxqz3MAgwjWuFs5a1pTc2PZNglOMjK6Vx6E03SAftJXl9nrti-r6X0_USsoN5NhHSnjWXxQeuVM__jQ5KSKGklAVVZ9Rhyhlh1GsxxuCd5kzfJ6RP-q-E9H1CmgldEiralw9rdruA_6P8HUkBjmcAii83AVBnFyA68AHBbdqn8B9rfgLPp6wC</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Yao, Hui-yuan</creator><creator>Han, Yan</creator><creator>Gao, Hui</creator><creator>Huang, Kun</creator><creator>Ge, Xing</creator><creator>Xu, Yuan-yuan</creator><creator>Xu, Ye-qing</creator><creator>Jin, Zhong-xiu</creator><creator>Sheng, Jie</creator><creator>Yan, Shuang-qin</creator><creator>Zhu, Peng</creator><creator>Hao, Jia-hu</creator><creator>Tao, Fang-biao</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0001-5179-0805</orcidid></search><sort><creationdate>201608</creationdate><title>Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns</title><author>Yao, Hui-yuan ; Han, Yan ; Gao, Hui ; Huang, Kun ; Ge, Xing ; Xu, Yuan-yuan ; Xu, Ye-qing ; Jin, Zhong-xiu ; Sheng, Jie ; Yan, Shuang-qin ; Zhu, Peng ; Hao, Jia-hu ; Tao, Fang-biao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-bb868ab15c6a10d5ba00bdde75ea2c35cbb03c6af2608ea9c1f0bb0f76a478ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biotransformation</topic><topic>China</topic><topic>Diethylhexyl Phthalate - urine</topic><topic>Endocrine disruption</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal Exposure</topic><topic>Newborn</topic><topic>Phthalate</topic><topic>Phthalic Acids - metabolism</topic><topic>Phthalic Acids - pharmacology</topic><topic>Phthalic Acids - urine</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - metabolism</topic><topic>Pregnancy women</topic><topic>Prospective Studies</topic><topic>Thyroid hormone</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Urinary metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Hui-yuan</creatorcontrib><creatorcontrib>Han, Yan</creatorcontrib><creatorcontrib>Gao, Hui</creatorcontrib><creatorcontrib>Huang, Kun</creatorcontrib><creatorcontrib>Ge, Xing</creatorcontrib><creatorcontrib>Xu, Yuan-yuan</creatorcontrib><creatorcontrib>Xu, Ye-qing</creatorcontrib><creatorcontrib>Jin, Zhong-xiu</creatorcontrib><creatorcontrib>Sheng, Jie</creatorcontrib><creatorcontrib>Yan, Shuang-qin</creatorcontrib><creatorcontrib>Zhu, Peng</creatorcontrib><creatorcontrib>Hao, Jia-hu</creatorcontrib><creatorcontrib>Tao, Fang-biao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Hui-yuan</au><au>Han, Yan</au><au>Gao, Hui</au><au>Huang, Kun</au><au>Ge, Xing</au><au>Xu, Yuan-yuan</au><au>Xu, Ye-qing</au><au>Jin, Zhong-xiu</au><au>Sheng, Jie</au><au>Yan, Shuang-qin</au><au>Zhu, Peng</au><au>Hao, Jia-hu</au><au>Tao, Fang-biao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2016-08</date><risdate>2016</risdate><volume>157</volume><spage>42</spage><epage>48</epage><pages>42-48</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><abstract>Animal and human studies have suggested that phthalate alters thyroid hormone concentrations. This study investigated the associations between phthalate exposure during the first trimester and thyroid hormones in pregnant women and their newborns. Pregnant women were enrolled from the prospective Ma’anshan Birth Cohort study in China. A standard questionnaire was completed by the women at the first antenatal visit. Seven phthalate metabolites were measured in one-spot urine at enrolment (10.0 ± 2.1 gestational weeks), as were thyroid hormone levels in maternal and cord sera. Multivariable linear regression showed that 1-standard deviation (SD) increase in natural log (ln)-transformed mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) was associated with 0.163 μg/dL (p = 0.001) and 0.173 μg/dL (p = 0.001) decreases in maternal total thyroxine (TT4). Both MEHP and MEHHP were negatively associated with maternal free thyroxine (FT4; β: −0.013, p < 0.001 and β: −0.011, p = 0.001, respectively) and positively associated with maternal thyroid-stimulating hormone (β: 0.101, p < 0.001; β: 0.132, p < 0.001, respectively). An inverse association was observed between monobenzyl phthalate and maternal TT4 and FT4. A 1-SD increase in ln-transformed monoethyl phthalate was inversely associated with maternal TT4 (β: −0.151, p = 0.002). By contrast, the concentrations of phthalate metabolites in urine were not associated with those of thyroid hormone in cord serum. Our analysis suggested that phthalate exposure during the first trimester disrupts maternal thyroid hormone levels.
•We assessed seven phthalate metabolites level of urine samples in pregnancy women.•We measured thyroid hormone (TH) concentrations in maternal and cord serum.•The study had a prospective design and large sample size.•It is the largest study examing THs change on phthalates exposure in pregnancy.•Phthalates exposure during the first trimester may disrupt maternal THs levels.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27208644</pmid><doi>10.1016/j.chemosphere.2016.05.023</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5179-0805</orcidid></addata></record> |
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| subjects | Adult Biotransformation China Diethylhexyl Phthalate - urine Endocrine disruption Female Humans Infant, Newborn Maternal Exposure Newborn Phthalate Phthalic Acids - metabolism Phthalic Acids - pharmacology Phthalic Acids - urine Pregnancy Pregnancy Trimester, First - metabolism Pregnancy women Prospective Studies Thyroid hormone Thyroid Hormones - blood Thyrotropin - blood Thyroxine - blood Urinary metabolites |
| title | Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns |
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