Sox7 controls arterial specification in conjunction with hey2 and efnb2 function

SoxF family members have been linked to arterio-venous specification events and human pathological conditions, but in contrast to Sox17 and Sox18, a detailed in vivo analysis of a Sox7 mutant model is still lacking. In this study we generated zebrafish sox7 mutants to understand the role of Sox7 dur...

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Veröffentlicht in:	Development (Cambridge) 2015-05, Vol.142 (9), p.1695-1704
Hauptverfasser:	Hermkens, Dorien M A, van Impel, Andreas, Urasaki, Akihiro, Bussmann, Jeroen, Duckers, Henricus J, Schulte-Merker, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiography Animals Animals, Genetically Modified - genetics Arteries - embryology Basic Helix-Loop-Helix Transcription Factors - genetics Danio rerio DNA Primers - genetics Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology In Situ Hybridization Morphogenesis - physiology Morpholinos - genetics Mutation - genetics Regional Blood Flow - physiology Reverse Transcriptase Polymerase Chain Reaction SOXF Transcription Factors - genetics SOXF Transcription Factors - metabolism Vascular Endothelial Growth Factor Receptor-3 - metabolism Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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