Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson’s disease
Abstract Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-hour waking-day motor assessment as the gold standard...
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| Veröffentlicht in: | Parkinsonism & related disorders 2016-06, Vol.27, p.98-101 |
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| creator | Raciti, L., MD, PhD Nicoletti, A., MD, MSc Mostile, G., MD, PhD Bonomo, R., MD Contrafatto, D., MD, PhD Dibilio, V., MD Luca, A., MD, PhD Sciacca, G., MD Cicero, C.E., MD Vasta, R., MD Zappia, M., MD |
| description | Abstract Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-hour waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-hour waking-day motor assessment in the study. Patients were clinically evaluated every 2 hours for 12 hours using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36-38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6-95.7) and a specificity of 43.5% (95%CI 23.2-65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients. |
| doi_str_mv | 10.1016/j.parkreldis.2016.03.008 |
| format | Article |
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Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-hour waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-hour waking-day motor assessment in the study. Patients were clinically evaluated every 2 hours for 12 hours using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36-38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6-95.7) and a specificity of 43.5% (95%CI 23.2-65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2016.03.008</identifier><identifier>PMID: 27017144</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Dopamine Agonists - therapeutic use ; Female ; Humans ; Levodopa - therapeutic use ; Male ; Middle Aged ; Motor fluctuations ; Motor Skills Disorders - diagnosis ; Motor Skills Disorders - drug therapy ; Motor Skills Disorders - epidemiology ; Neurology ; Parkinson Disease - diagnosis ; Parkinson Disease - drug therapy ; Parkinson Disease - epidemiology ; Sensitivity and specificity ; Severity of Illness Index ; Single-Blind Method ; UPDRS</subject><ispartof>Parkinsonism & related disorders, 2016-06, Vol.27, p.98-101</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-fd0265babad2df0015a9ca7bec87dcf810583231ccf44ad8d6314ede5e8e78573</citedby><cites>FETCH-LOGICAL-c462t-fd0265babad2df0015a9ca7bec87dcf810583231ccf44ad8d6314ede5e8e78573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1353802016300621$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27017144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raciti, L., MD, PhD</creatorcontrib><creatorcontrib>Nicoletti, A., MD, MSc</creatorcontrib><creatorcontrib>Mostile, G., MD, PhD</creatorcontrib><creatorcontrib>Bonomo, R., MD</creatorcontrib><creatorcontrib>Contrafatto, D., MD, PhD</creatorcontrib><creatorcontrib>Dibilio, V., MD</creatorcontrib><creatorcontrib>Luca, A., MD, PhD</creatorcontrib><creatorcontrib>Sciacca, G., MD</creatorcontrib><creatorcontrib>Cicero, C.E., MD</creatorcontrib><creatorcontrib>Vasta, R., MD</creatorcontrib><creatorcontrib>Zappia, M., MD</creatorcontrib><title>Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson’s disease</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-hour waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-hour waking-day motor assessment in the study. Patients were clinically evaluated every 2 hours for 12 hours using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36-38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6-95.7) and a specificity of 43.5% (95%CI 23.2-65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients.</description><subject>Aged</subject><subject>Dopamine Agonists - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor fluctuations</subject><subject>Motor Skills Disorders - diagnosis</subject><subject>Motor Skills Disorders - drug therapy</subject><subject>Motor Skills Disorders - epidemiology</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - epidemiology</subject><subject>Sensitivity and specificity</subject><subject>Severity of Illness Index</subject><subject>Single-Blind Method</subject><subject>UPDRS</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstuFDEQRS1ERB7wC8hLNt0pP7rt2SBBeEWKlIiQbC2PXRae9LQHuxspO36D3-NL8GQGkNjAytbVqYfuLUIog5YB609X7cbmu4yDj6XlVWlBtAD6ETliWommY7x_XP-iE40GDofkuJQVAKgOxBNyyBUwxaQ8IubWDtHbKaaRpkCnz0hvrt58vKYF3YN4fktDytTjtBcqtU5TlcIwu2l-KC00jvSqrhTHksYf374XWjdDW_ApOQh2KPhs_56Qm3dvP519aC4u35-fvbponOz51AQPvO-Wdmk99wGAdXbhrFqi08q7oBl0WnDBnAtSWq99L5hEjx1qVLpT4oS82PXd5PRlxjKZdSwOh8GOmOZimAbds4VU4t-oWgjOpJCLiuod6nIqJWMwmxzXNt8bBmabhFmZP0mYbRIGhKlJ1NLn-ynzco3-d-Ev6yvwegdgteVrxGyKizg69DFXq41P8X-mvPyriRviGJ0d7vAeyyrNeay2G2YKN2CutxexPQjWC4CeM_ETMsu1gQ</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Raciti, L., MD, PhD</creator><creator>Nicoletti, A., MD, MSc</creator><creator>Mostile, G., MD, PhD</creator><creator>Bonomo, R., MD</creator><creator>Contrafatto, D., MD, PhD</creator><creator>Dibilio, V., MD</creator><creator>Luca, A., MD, PhD</creator><creator>Sciacca, G., MD</creator><creator>Cicero, C.E., MD</creator><creator>Vasta, R., MD</creator><creator>Zappia, M., MD</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160601</creationdate><title>Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson’s disease</title><author>Raciti, L., MD, PhD ; Nicoletti, A., MD, MSc ; Mostile, G., MD, PhD ; Bonomo, R., MD ; Contrafatto, D., MD, PhD ; Dibilio, V., MD ; Luca, A., MD, PhD ; Sciacca, G., MD ; Cicero, C.E., MD ; Vasta, R., MD ; Zappia, M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-fd0265babad2df0015a9ca7bec87dcf810583231ccf44ad8d6314ede5e8e78573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Dopamine Agonists - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor fluctuations</topic><topic>Motor Skills Disorders - diagnosis</topic><topic>Motor Skills Disorders - drug therapy</topic><topic>Motor Skills Disorders - epidemiology</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - epidemiology</topic><topic>Sensitivity and specificity</topic><topic>Severity of Illness Index</topic><topic>Single-Blind Method</topic><topic>UPDRS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raciti, L., MD, PhD</creatorcontrib><creatorcontrib>Nicoletti, A., MD, MSc</creatorcontrib><creatorcontrib>Mostile, G., MD, PhD</creatorcontrib><creatorcontrib>Bonomo, R., MD</creatorcontrib><creatorcontrib>Contrafatto, D., MD, PhD</creatorcontrib><creatorcontrib>Dibilio, V., MD</creatorcontrib><creatorcontrib>Luca, A., MD, PhD</creatorcontrib><creatorcontrib>Sciacca, G., MD</creatorcontrib><creatorcontrib>Cicero, C.E., MD</creatorcontrib><creatorcontrib>Vasta, R., MD</creatorcontrib><creatorcontrib>Zappia, M., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raciti, L., MD, PhD</au><au>Nicoletti, A., MD, MSc</au><au>Mostile, G., MD, PhD</au><au>Bonomo, R., MD</au><au>Contrafatto, D., MD, PhD</au><au>Dibilio, V., MD</au><au>Luca, A., MD, PhD</au><au>Sciacca, G., MD</au><au>Cicero, C.E., MD</au><au>Vasta, R., MD</au><au>Zappia, M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson’s disease</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>27</volume><spage>98</spage><epage>101</epage><pages>98-101</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract Introduction The UPDRS-IV represents the most common screening tool to assess motor fluctuations in patients with PD despite the lack of a clinimetric validation. Objectives We evaluated sensitivity and specificity of UPDRS-IV using a 12-hour waking-day motor assessment as the gold standard. Methods We consecutively enrolled PD patients who underwent a 12-hour waking-day motor assessment in the study. Patients were clinically evaluated every 2 hours for 12 hours using the UPDRS-III. Motor scores were reported as a line graph and six blinded raters classified patients as having or not having motor fluctuations. The UPDRS-IV was used in order to assess the presence of predictable and unpredictable motor fluctuations according to items 36-38. Results Sixty two PD patients were enrolled in the study. According to the raters’ evaluations, 39 (62.9%) were classified as having motor fluctuations, while according to the UPDRS-IV 47 (75.8%) presented a motor fluctuation giving a sensitivity of 87.2% (95%CI 72.6-95.7) and a specificity of 43.5% (95%CI 23.2-65.5). Conclusion Our study results confirm the high level of sensitivity with a lower level of specificity of UPDRS-IV to screen motor fluctuations in PD patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27017144</pmid><doi>10.1016/j.parkreldis.2016.03.008</doi><tpages>4</tpages></addata></record> |
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| ispartof | Parkinsonism & related disorders, 2016-06, Vol.27, p.98-101 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Dopamine Agonists - therapeutic use Female Humans Levodopa - therapeutic use Male Middle Aged Motor fluctuations Motor Skills Disorders - diagnosis Motor Skills Disorders - drug therapy Motor Skills Disorders - epidemiology Neurology Parkinson Disease - diagnosis Parkinson Disease - drug therapy Parkinson Disease - epidemiology Sensitivity and specificity Severity of Illness Index Single-Blind Method UPDRS |
| title | Validation of the UPDRS section IV for detection of motor fluctuations in Parkinson’s disease |
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