Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)
Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes...
Gespeichert in:
| Veröffentlicht in: | European heart journal 2014-10, Vol.35 (39), p.2714-2721 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2721 |
|---|---|
| container_issue | 39 |
| container_start_page | 2714 |
| container_title | European heart journal |
| container_volume | 35 |
| creator | Wong, Chih M Hawkins, Nathaniel M Petrie, Mark C Jhund, Pardeep S Gardner, Roy S Ariti, Cono A Poppe, Katrina K Earle, Nikki Whalley, Gillian A Squire, Iain B Doughty, Robert N McMurray, John J V |
| description | Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Patients were stratified into six age categories: |
| doi_str_mv | 10.1093/eurheartj/ehu216 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808619242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1612985158</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-d0e8abb634e52119d97fb25ee332a7f6cd839097d8462862fbb187c6da764d263</originalsourceid><addsrcrecordid>eNqFkT1PwzAQhi0EoqWwMyGPZQj1VxybrapoQGrFAhJb5CQXkipNgh0P_fc0SunKdMO9zyPdvQjdU_JEieYL8LYEY_vdAkrPqLxAUxoyFmgpwks0JVSHgZTqa4JunNsRQpSk8hpNmNBCcKanKHsdeFyYqvYWcNXgQ-ubb7C4M30FTe-ecV8C3kJvAtOY-uAqh-O6TU2NY9v6bmBWpW2bKsOjbH2SzbfLOH5bPd6iq8LUDu5Oc4Y-1y8fq9dg835cLzdBxiPRBzkBZdJUcgEho1TnOipSFgJwzkxUyCxXXBMd5UpIpiQr0pSqKJO5iaTImeQzNB-9nW1_PLg-2Vcug7o2DbTeJVQN92sm2P9RSZlWIQ3VMUrGaGZb5ywUSWervbGHhJJkaCE5t5CMLRyRh5Pdp3vIz8Df2_kvG9mFTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1612985158</pqid></control><display><type>article</type><title>Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Wong, Chih M ; Hawkins, Nathaniel M ; Petrie, Mark C ; Jhund, Pardeep S ; Gardner, Roy S ; Ariti, Cono A ; Poppe, Katrina K ; Earle, Nikki ; Whalley, Gillian A ; Squire, Iain B ; Doughty, Robert N ; McMurray, John J V</creator><creatorcontrib>Wong, Chih M ; Hawkins, Nathaniel M ; Petrie, Mark C ; Jhund, Pardeep S ; Gardner, Roy S ; Ariti, Cono A ; Poppe, Katrina K ; Earle, Nikki ; Whalley, Gillian A ; Squire, Iain B ; Doughty, Robert N ; McMurray, John J V ; MAGGIC Investigators</creatorcontrib><description>Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Patients were stratified into six age categories: <40 (n = 876), 40-49 (n = 2638), 50-59 (n = 6894), 60-69 (n = 12 071), 70-79 (n = 13 368), and ≥80 years (n = 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (<40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P < 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (<40, 40-49, and 50-59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively.
Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehu216</identifier><identifier>PMID: 24944329</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Blood Pressure - physiology ; Cardiotonic Agents - therapeutic use ; Chronic Disease ; Epidemiologic Methods ; Female ; Global Health ; Heart Failure - drug therapy ; Heart Failure - epidemiology ; Heart Failure - physiopathology ; Heart Rate - physiology ; Humans ; Male ; Middle Aged ; Ventricular Dysfunction, Left - drug therapy ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>European heart journal, 2014-10, Vol.35 (39), p.2714-2721</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-d0e8abb634e52119d97fb25ee332a7f6cd839097d8462862fbb187c6da764d263</citedby><cites>FETCH-LOGICAL-c374t-d0e8abb634e52119d97fb25ee332a7f6cd839097d8462862fbb187c6da764d263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24944329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Chih M</creatorcontrib><creatorcontrib>Hawkins, Nathaniel M</creatorcontrib><creatorcontrib>Petrie, Mark C</creatorcontrib><creatorcontrib>Jhund, Pardeep S</creatorcontrib><creatorcontrib>Gardner, Roy S</creatorcontrib><creatorcontrib>Ariti, Cono A</creatorcontrib><creatorcontrib>Poppe, Katrina K</creatorcontrib><creatorcontrib>Earle, Nikki</creatorcontrib><creatorcontrib>Whalley, Gillian A</creatorcontrib><creatorcontrib>Squire, Iain B</creatorcontrib><creatorcontrib>Doughty, Robert N</creatorcontrib><creatorcontrib>McMurray, John J V</creatorcontrib><creatorcontrib>MAGGIC Investigators</creatorcontrib><title>Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Patients were stratified into six age categories: <40 (n = 876), 40-49 (n = 2638), 50-59 (n = 6894), 60-69 (n = 12 071), 70-79 (n = 13 368), and ≥80 years (n = 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (<40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P < 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (<40, 40-49, and 50-59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively.
Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Pressure - physiology</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Chronic Disease</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Global Health</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ventricular Dysfunction, Left - drug therapy</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1PwzAQhi0EoqWwMyGPZQj1VxybrapoQGrFAhJb5CQXkipNgh0P_fc0SunKdMO9zyPdvQjdU_JEieYL8LYEY_vdAkrPqLxAUxoyFmgpwks0JVSHgZTqa4JunNsRQpSk8hpNmNBCcKanKHsdeFyYqvYWcNXgQ-ubb7C4M30FTe-ecV8C3kJvAtOY-uAqh-O6TU2NY9v6bmBWpW2bKsOjbH2SzbfLOH5bPd6iq8LUDu5Oc4Y-1y8fq9dg835cLzdBxiPRBzkBZdJUcgEho1TnOipSFgJwzkxUyCxXXBMd5UpIpiQr0pSqKJO5iaTImeQzNB-9nW1_PLg-2Vcug7o2DbTeJVQN92sm2P9RSZlWIQ3VMUrGaGZb5ywUSWervbGHhJJkaCE5t5CMLRyRh5Pdp3vIz8Df2_kvG9mFTQ</recordid><startdate>20141014</startdate><enddate>20141014</enddate><creator>Wong, Chih M</creator><creator>Hawkins, Nathaniel M</creator><creator>Petrie, Mark C</creator><creator>Jhund, Pardeep S</creator><creator>Gardner, Roy S</creator><creator>Ariti, Cono A</creator><creator>Poppe, Katrina K</creator><creator>Earle, Nikki</creator><creator>Whalley, Gillian A</creator><creator>Squire, Iain B</creator><creator>Doughty, Robert N</creator><creator>McMurray, John J V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20141014</creationdate><title>Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)</title><author>Wong, Chih M ; Hawkins, Nathaniel M ; Petrie, Mark C ; Jhund, Pardeep S ; Gardner, Roy S ; Ariti, Cono A ; Poppe, Katrina K ; Earle, Nikki ; Whalley, Gillian A ; Squire, Iain B ; Doughty, Robert N ; McMurray, John J V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-d0e8abb634e52119d97fb25ee332a7f6cd839097d8462862fbb187c6da764d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Pressure - physiology</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Chronic Disease</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Global Health</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ventricular Dysfunction, Left - drug therapy</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Chih M</creatorcontrib><creatorcontrib>Hawkins, Nathaniel M</creatorcontrib><creatorcontrib>Petrie, Mark C</creatorcontrib><creatorcontrib>Jhund, Pardeep S</creatorcontrib><creatorcontrib>Gardner, Roy S</creatorcontrib><creatorcontrib>Ariti, Cono A</creatorcontrib><creatorcontrib>Poppe, Katrina K</creatorcontrib><creatorcontrib>Earle, Nikki</creatorcontrib><creatorcontrib>Whalley, Gillian A</creatorcontrib><creatorcontrib>Squire, Iain B</creatorcontrib><creatorcontrib>Doughty, Robert N</creatorcontrib><creatorcontrib>McMurray, John J V</creatorcontrib><creatorcontrib>MAGGIC Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Chih M</au><au>Hawkins, Nathaniel M</au><au>Petrie, Mark C</au><au>Jhund, Pardeep S</au><au>Gardner, Roy S</au><au>Ariti, Cono A</au><au>Poppe, Katrina K</au><au>Earle, Nikki</au><au>Whalley, Gillian A</au><au>Squire, Iain B</au><au>Doughty, Robert N</au><au>McMurray, John J V</au><aucorp>MAGGIC Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2014-10-14</date><risdate>2014</risdate><volume>35</volume><issue>39</issue><spage>2714</spage><epage>2721</epage><pages>2714-2721</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Patients were stratified into six age categories: <40 (n = 876), 40-49 (n = 2638), 50-59 (n = 6894), 60-69 (n = 12 071), 70-79 (n = 13 368), and ≥80 years (n = 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (<40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P < 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (<40, 40-49, and 50-59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively.
Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients.</abstract><cop>England</cop><pmid>24944329</pmid><doi>10.1093/eurheartj/ehu216</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 2014-10, Vol.35 (39), p.2714-2721 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808619242 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Distribution Aged Aged, 80 and over Blood Pressure - physiology Cardiotonic Agents - therapeutic use Chronic Disease Epidemiologic Methods Female Global Health Heart Failure - drug therapy Heart Failure - epidemiology Heart Failure - physiopathology Heart Rate - physiology Humans Male Middle Aged Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - physiopathology |
| title | Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T23%3A40%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heart%20failure%20in%20younger%20patients:%20the%20Meta-analysis%20Global%20Group%20in%20Chronic%20Heart%20Failure%20(MAGGIC)&rft.jtitle=European%20heart%20journal&rft.au=Wong,%20Chih%20M&rft.aucorp=MAGGIC%20Investigators&rft.date=2014-10-14&rft.volume=35&rft.issue=39&rft.spage=2714&rft.epage=2721&rft.pages=2714-2721&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/eurheartj/ehu216&rft_dat=%3Cproquest_cross%3E1612985158%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1612985158&rft_id=info:pmid/24944329&rfr_iscdi=true |