Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics
Cellular immune responses that protect against tumors typically have been attributed to CD8 T cells. However, CD4 T cells also play a central role. It was shown recently that, in a patient with metastatic cholangiocarcinoma, CD4 T cells specific for a peptide from a mutated region of ERBB2IP could a...
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| Veröffentlicht in: | The Journal of immunology (1950) 2015-03, Vol.194 (5), p.2049-2056 |
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| container_title | The Journal of immunology (1950) |
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| creator | Zanetti, Maurizio |
| description | Cellular immune responses that protect against tumors typically have been attributed to CD8 T cells. However, CD4 T cells also play a central role. It was shown recently that, in a patient with metastatic cholangiocarcinoma, CD4 T cells specific for a peptide from a mutated region of ERBB2IP could arrest tumor progression. This and other recent findings highlight new opportunities for CD4 T cells in cancer immunotherapy. In this article, I discuss the role and regulation of CD4 T cells in response to tumor Ags. Emphasis is placed on the types of Ags and mechanisms that elicit tumor-protective responses. I discuss the advantages and drawbacks of cancer immunotherapy through personalized genomics. These considerations should help to guide the design of next-generation therapeutic cancer vaccines. |
| doi_str_mv | 10.4049/jimmunol.1402669 |
| format | Article |
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| ispartof | The Journal of immunology (1950), 2015-03, Vol.194 (5), p.2049-2056 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Bile Duct Neoplasms - genetics Bile Duct Neoplasms - immunology Bile Duct Neoplasms - pathology Bile Duct Neoplasms - prevention & control Bile Duct Neoplasms - therapy Bile Ducts, Intrahepatic - immunology Bile Ducts, Intrahepatic - pathology Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cholangiocarcinoma - genetics Cholangiocarcinoma - immunology Cholangiocarcinoma - pathology Cholangiocarcinoma - prevention & control Cholangiocarcinoma - therapy Gene Expression Genomics Humans Immunotherapy Mutation - genetics Mutation - immunology Neoplasm Metastasis Precision Medicine |
| title | Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics |
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