Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype
Background Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese‐asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with...
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| Veröffentlicht in: | Allergy (Copenhagen) 2016-07, Vol.71 (7), p.1037-1047 |
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| creator | Scott, H. A. Gibson, P. G. Garg, M. L. Upham, J. W. Wood, L. G. |
| description | Background
Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese‐asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma.
Methods
Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive‐aged (50 years old; n = 45). Thirteen (36.1%) reproductive‐aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers.
Results
Obese reproductive‐aged females had higher sputum %neutrophils than nonobese reproductive‐aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C‐reactive protein and IL‐6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive‐aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015).
Conclusions
This study suggests that sex hormones and systemic inflammation may be mediating the obese‐asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive‐aged females warrants further investigation. |
| doi_str_mv | 10.1111/all.12891 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808617502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808617502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4521-de7f293a0d1e01f901bc1530cfacbd90cc01b98e71890b07d622a17740515ed83</originalsourceid><addsrcrecordid>eNqF0UFLHDEUB_BQLHXVHvwCEvDSHkbfy2w2yVGWqoUFD9XzkMm8YUcmkzWZQffWj9DP2E_S6NoeCmIuLzx-_OHxZ-wY4QzzO7d9f4ZCG_zAZlgaXRhj5B6bAYIs5rLU--wgpXsAUMLAJ7YvVP6CljN294Oe-DpEHwZK3A4NT9s0ku8c74a2t97bsQsDt5G4D83U2zHExEPLxzXxUFOi3z9_2TSuveWbNQ1h3G7oiH1sbZ_o8-s8ZHeX326X18Xq5ur78mJVuLkUWDSkWmFKCw0SYGsAa4eyBNdaVzcGnMsbo0mhNlCDahZCWFRqDhIlNbo8ZF92uZsYHiZKY-W75Kjv7UBhShVq0AtUEsT7VBklhMFynunpf_Q-THHIhzyrBRgUSmb1dadcDClFaqtN7LyN2wqheq6lyrVUL7Vke_KaONWemn_ybw8ZnO_AY9fT9u2k6mK12kX-AWYUlp8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1796091275</pqid></control><display><type>article</type><title>Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Scott, H. A. ; Gibson, P. G. ; Garg, M. L. ; Upham, J. W. ; Wood, L. G.</creator><creatorcontrib>Scott, H. A. ; Gibson, P. G. ; Garg, M. L. ; Upham, J. W. ; Wood, L. G.</creatorcontrib><description>Background
Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese‐asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma.
Methods
Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive‐aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive‐aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers.
Results
Obese reproductive‐aged females had higher sputum %neutrophils than nonobese reproductive‐aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C‐reactive protein and IL‐6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive‐aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015).
Conclusions
This study suggests that sex hormones and systemic inflammation may be mediating the obese‐asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive‐aged females warrants further investigation.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.12891</identifier><identifier>PMID: 27007085</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Asthma ; Asthma - epidemiology ; Asthma - etiology ; Asthma - metabolism ; Biomarkers ; Contraceptives, Oral - adverse effects ; Female ; Genotype & phenotype ; Gonadal Steroid Hormones - metabolism ; Hormones ; Humans ; Inflammation ; Inflammation - complications ; Inflammation - metabolism ; Inflammation Mediators - metabolism ; Male ; Middle Aged ; neutrophil ; Neutrophils - immunology ; Neutrophils - metabolism ; Obesity ; Obesity - complications ; Obesity - metabolism ; Phenotype ; Respiratory Function Tests ; sex hormone ; Sputum - cytology ; systemic inflammation</subject><ispartof>Allergy (Copenhagen), 2016-07, Vol.71 (7), p.1037-1047</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4521-de7f293a0d1e01f901bc1530cfacbd90cc01b98e71890b07d622a17740515ed83</citedby><cites>FETCH-LOGICAL-c4521-de7f293a0d1e01f901bc1530cfacbd90cc01b98e71890b07d622a17740515ed83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.12891$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.12891$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27007085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, H. A.</creatorcontrib><creatorcontrib>Gibson, P. G.</creatorcontrib><creatorcontrib>Garg, M. L.</creatorcontrib><creatorcontrib>Upham, J. W.</creatorcontrib><creatorcontrib>Wood, L. G.</creatorcontrib><title>Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese‐asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma.
Methods
Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive‐aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive‐aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers.
Results
Obese reproductive‐aged females had higher sputum %neutrophils than nonobese reproductive‐aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C‐reactive protein and IL‐6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive‐aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015).
Conclusions
This study suggests that sex hormones and systemic inflammation may be mediating the obese‐asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive‐aged females warrants further investigation.</description><subject>Adult</subject><subject>Aged</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Asthma - metabolism</subject><subject>Biomarkers</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Hormones</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - metabolism</subject><subject>Inflammation Mediators - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neutrophil</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><subject>Phenotype</subject><subject>Respiratory Function Tests</subject><subject>sex hormone</subject><subject>Sputum - cytology</subject><subject>systemic inflammation</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFLHDEUB_BQLHXVHvwCEvDSHkbfy2w2yVGWqoUFD9XzkMm8YUcmkzWZQffWj9DP2E_S6NoeCmIuLzx-_OHxZ-wY4QzzO7d9f4ZCG_zAZlgaXRhj5B6bAYIs5rLU--wgpXsAUMLAJ7YvVP6CljN294Oe-DpEHwZK3A4NT9s0ku8c74a2t97bsQsDt5G4D83U2zHExEPLxzXxUFOi3z9_2TSuveWbNQ1h3G7oiH1sbZ_o8-s8ZHeX326X18Xq5ur78mJVuLkUWDSkWmFKCw0SYGsAa4eyBNdaVzcGnMsbo0mhNlCDahZCWFRqDhIlNbo8ZF92uZsYHiZKY-W75Kjv7UBhShVq0AtUEsT7VBklhMFynunpf_Q-THHIhzyrBRgUSmb1dadcDClFaqtN7LyN2wqheq6lyrVUL7Vke_KaONWemn_ybw8ZnO_AY9fT9u2k6mK12kX-AWYUlp8</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Scott, H. A.</creator><creator>Gibson, P. G.</creator><creator>Garg, M. L.</creator><creator>Upham, J. W.</creator><creator>Wood, L. G.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype</title><author>Scott, H. A. ; Gibson, P. G. ; Garg, M. L. ; Upham, J. W. ; Wood, L. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4521-de7f293a0d1e01f901bc1530cfacbd90cc01b98e71890b07d622a17740515ed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Asthma - metabolism</topic><topic>Biomarkers</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Hormones</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - metabolism</topic><topic>Inflammation Mediators - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neutrophil</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><topic>Phenotype</topic><topic>Respiratory Function Tests</topic><topic>sex hormone</topic><topic>Sputum - cytology</topic><topic>systemic inflammation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, H. A.</creatorcontrib><creatorcontrib>Gibson, P. G.</creatorcontrib><creatorcontrib>Garg, M. L.</creatorcontrib><creatorcontrib>Upham, J. W.</creatorcontrib><creatorcontrib>Wood, L. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, H. A.</au><au>Gibson, P. G.</au><au>Garg, M. L.</au><au>Upham, J. W.</au><au>Wood, L. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2016-07</date><risdate>2016</risdate><volume>71</volume><issue>7</issue><spage>1037</spage><epage>1047</epage><pages>1037-1047</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background
Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese‐asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma.
Methods
Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive‐aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive‐aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers.
Results
Obese reproductive‐aged females had higher sputum %neutrophils than nonobese reproductive‐aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C‐reactive protein and IL‐6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive‐aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015).
Conclusions
This study suggests that sex hormones and systemic inflammation may be mediating the obese‐asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive‐aged females warrants further investigation.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>27007085</pmid><doi>10.1111/all.12891</doi><tpages>11</tpages></addata></record> |
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| ispartof | Allergy (Copenhagen), 2016-07, Vol.71 (7), p.1037-1047 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Asthma Asthma - epidemiology Asthma - etiology Asthma - metabolism Biomarkers Contraceptives, Oral - adverse effects Female Genotype & phenotype Gonadal Steroid Hormones - metabolism Hormones Humans Inflammation Inflammation - complications Inflammation - metabolism Inflammation Mediators - metabolism Male Middle Aged neutrophil Neutrophils - immunology Neutrophils - metabolism Obesity Obesity - complications Obesity - metabolism Phenotype Respiratory Function Tests sex hormone Sputum - cytology systemic inflammation |
| title | Sex hormones and systemic inflammation are modulators of the obese‐asthma phenotype |
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