AT-58 JCOG0911 INTEGRA TRIAL: A RANDOMIZED SCREENING PHASE II TRIAL OF CHEMORADIOTHERAPY WITH INTERFERON beta PLUS TEMOZOLOMIDE VERSUS CHEMORADIOTHERAPY WITH TEMOZOLOMIDE ALONE FOR NEWLY-DIAGNOSED GLIOBLASTOMA

BACKGROUND: Our lab experiments showed that interferon beta (IFN beta ) markedly enhanced chemosensitivity to temozolomide (TMZ) via the down-regulation of MGMT transcription. Followed by phase I trial, INTEGRA trial investigated the efficacy of TMZ + IFN beta therapy by a randomized screening desig...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2014-11, Vol.16 (suppl 5), p.v21-v21
Hauptverfasser:	Wakabayashi, Toshihiko, Natsume, Atsushi, Mizusawa, Junki, Katayama, Hiroshi, Fukuda, Haruhiko, Shibui, Soichiro, BTSG, Members JCOG
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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