Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism

Highlights • How to prevent secondary brain injury is the key to improve clinical outcomes in glioma patients undergoing craniotomy. • The brain protective effect of dexmedetomidine in anesthesia of craniotomy resection of glioma has not been reported. • Dexmedetomidine vein pump injection before an...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2016-07, Vol.146, p.105-108
Hauptverfasser:	Luo, Xiahong, Zheng, Xia, Huang, Hougang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood pressure Brain damage Brain Neoplasms - blood Brain Neoplasms - surgery Brain protection Conflicts of interest Craniotomy - methods Cytokines Dexmedetomidine Dexmedetomidine - administration & dosage Dexmedetomidine - pharmacology Enzymes Female Glioma Glioma - blood Glioma - surgery Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacology Intubation Male Middle Aged Neurology Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neurosurgery Outcome Assessment (Health Care) Oxidative stress Statistical analysis Surgery Traumatic brain injury Tumor necrosis factor-TNF Veins & arteries
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Zusammenfassung:	Highlights • How to prevent secondary brain injury is the key to improve clinical outcomes in glioma patients undergoing craniotomy. • The brain protective effect of dexmedetomidine in anesthesia of craniotomy resection of glioma has not been reported. • Dexmedetomidine vein pump injection before anesthesia induction can effectively reduce brain damage caused by craniotomy
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2016.05.004