A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet

Background: We have previously shown that antagonism of the mineralocorticoid receptor (MR) results in a potent antiadipogenic activity, in vitro and in vivo. Excessive glucocorticoid exposure is associated with obesity and related disorders in humans and mice. Methods: In this study, responses to a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International Journal of Obesity 2016-06, Vol.40 (6), p.964-972
Hauptverfasser:	Mammi, C, Marzolla, V, Armani, A, Feraco, A, Antelmi, A, Maslak, E, Chlopicki, S, Cinti, F, Hunt, H, Fabbri, A, Caprio, M
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14/63 631/45/612/388 631/92/436/2387 64/60 692/163 692/699 692/699/2743/393 692/700/565 Adipocytes Adiponectin Adipose tissue Adipose Tissue - drug effects Aldosterone Analysis Animals Body fat Body weight Body weight gain Corticosteroids Dexamethasone Diet Diet, High-Fat Disease Models, Animal Dosage and administration Endocrinology Epidemiology Female Food intake Glucocorticoids Glucose Glucose tolerance Health Promotion and Disease Prevention High fat diet Insulin resistance Internal Medicine Laboratories Leptin Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mifepristone Mifepristone - pharmacology Mineralocorticoid Receptor Antagonists - pharmacology Mineralocorticoids Obesity original-article Plasma levels Preadipocytes Public Health Receptors Receptors, Glucocorticoid - antagonists & inhibitors Steroids Therapeutic targets Thymine - analogs & derivatives Thymine - pharmacology Weight gain Weight Gain - drug effects Weight reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!