Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial

Summary Background Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype 1 or 4 and advanced liver disease. Methods We did an open-label st...

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Veröffentlicht in:	The Lancet infectious diseases 2016-06, Vol.16 (6), p.685-697
Hauptverfasser:	Manns, Michael, Prof, Samuel, Didier, Prof, Gane, Edward J, Prof, Mutimer, David, Prof, McCaughan, Geoff, Prof, Buti, Maria, Prof, Prieto, MartÍn, MD, Calleja, José Luis, MD, Peck-Radosavljevic, Markus, Prof, Müllhaupt, Beat, Prof, Agarwal, Kosh, MD, Angus, Peter, Prof, Yoshida, Eric M, MD, Colombo, Massimo, Prof, Rizzetto, Mario, Prof, Dvory-Sobol, Hadas, PhD, Denning, Jill, MA, Arterburn, Sarah, MS, Pang, Phillip S, MD, Brainard, Diana, MD, McHutchison, John G, MD, Dufour, Jean-François, MD, Van Vlierberghe, Hans, Prof, van Hoek, Bart, Prof, Forns, Xavier, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - therapeutic use Benzimidazoles - therapeutic use Drug Therapy, Combination Female Fluorenes - therapeutic use Genotype Genotype & phenotype Global Health Hepacivirus - classification Hepacivirus - drug effects Hepacivirus - genetics Hepatitis Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - mortality Humans Hypothesis testing Infections Infectious Disease Infectious diseases Liver Liver Cirrhosis - drug therapy Liver Cirrhosis - mortality Liver Cirrhosis - virology Liver diseases Liver transplantation Male Middle Aged Mortality Ribavirin - therapeutic use RNA, Viral Time Factors Transplants & implants Treatment Outcome Uridine Monophosphate - analogs & derivatives Uridine Monophosphate - therapeutic use Viral Load
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