Taste intensity modulates effective connectivity from the insular cortex to the thalamus in humans
Evaluation of taste intensity is one of the most important perceptual abilities in our daily life. In contrast with extensive research findings regarding the spatial representation of taste in the insula and thalamus, little is known about how the thalamus and insula communicate and reciprocally inf...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2016-07, Vol.135, p.214-222 |
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| creator | Yeung, Andy Wai Kan Tanabe, Hiroki C. Suen, Justin Long Kiu Goto, Tazuko K. |
| description | Evaluation of taste intensity is one of the most important perceptual abilities in our daily life. In contrast with extensive research findings regarding the spatial representation of taste in the insula and thalamus, little is known about how the thalamus and insula communicate and reciprocally influence their activities for processing taste intensity. To examine this neurophysiological relationship, we investigated the modulatory effect of intensity of saltiness on connections in the network processing taste signals in the human brain. These “effective connectivity” relationships refer to the neurophysiological influence (including direction and strength of influence) of one brain region on another. Healthy adults (N=34), including 17 males and 17 females (mean age=21.3years, SD=2.4; mean body mass index (BMI)=20.2kg/m2, SD=2.1) underwent functional magnetic resonance imaging as they tasted three concentrations of sodium chloride solutions. By effective connectivity analysis with dynamic causal modeling, we show that taste intensity enhances top-down signal transmission from the insular cortex to the thalamus. These results are the first to demonstrate the modulatory effect of taste intensity on the taste network in the human brain.
•We examined brain taste network that processes salty taste intensity.•Salty intensity of sodium chloride modulates backward insular-thalamic connection.•Taste intensity signals enhance top-down insular-thalamic signal transmission. |
| doi_str_mv | 10.1016/j.neuroimage.2016.04.057 |
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In contrast with extensive research findings regarding the spatial representation of taste in the insula and thalamus, little is known about how the thalamus and insula communicate and reciprocally influence their activities for processing taste intensity. To examine this neurophysiological relationship, we investigated the modulatory effect of intensity of saltiness on connections in the network processing taste signals in the human brain. These “effective connectivity” relationships refer to the neurophysiological influence (including direction and strength of influence) of one brain region on another. Healthy adults (N=34), including 17 males and 17 females (mean age=21.3years, SD=2.4; mean body mass index (BMI)=20.2kg/m2, SD=2.1) underwent functional magnetic resonance imaging as they tasted three concentrations of sodium chloride solutions. By effective connectivity analysis with dynamic causal modeling, we show that taste intensity enhances top-down signal transmission from the insular cortex to the thalamus. These results are the first to demonstrate the modulatory effect of taste intensity on the taste network in the human brain.
•We examined brain taste network that processes salty taste intensity.•Salty intensity of sodium chloride modulates backward insular-thalamic connection.•Taste intensity signals enhance top-down insular-thalamic signal transmission.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27132544</pmid><doi>10.1016/j.neuroimage.2016.04.057</doi><tpages>9</tpages></addata></record> |
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| subjects | Administration, Oral Animals Brain research Cerebral Cortex - physiology Communication Connectome - methods Dose-Response Relationship, Drug Dynamic causal modeling Female Functional magnetic resonance imaging Humans Insular cortex Magnetic Resonance Imaging - methods Male Medical imaging Nerve Net - drug effects Nerve Net - physiology Neural Pathways - drug effects Neural Pathways - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology NMR Nuclear magnetic resonance Rodents Sodium chloride Sodium Chloride - administration & dosage Studies Taste - drug effects Taste - physiology Taste intensity Taste Perception - drug effects Taste Perception - physiology Thalamus Thalamus - drug effects Thalamus - physiology Young Adult |
| title | Taste intensity modulates effective connectivity from the insular cortex to the thalamus in humans |
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