Computational Systems Biology Approach Predicts Regulators and Targets of microRNAs and Their Genomic Hotspots in Apoptosis Process

Novel computational systems biology tools such as common targets analysis, common regulators analysis, pathway discovery, and transcriptomic-based hotspot discovery provide new opportunities in understanding of apoptosis molecular mechanisms. In this study, after measuring the global contribution of...

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Veröffentlicht in:	Molecular biotechnology 2016-07, Vol.58 (7), p.460-479
Hauptverfasser:	Alanazi, Ibrahim O., Ebrahimie, Esmaeil
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Apoptosis Apoptosis - drug effects Biochemistry Biological Techniques Biotechnology Cell Biology Cell Line Chemistry Chemistry and Materials Science Epidermal Growth Factor - pharmacology Genomics Genomics - methods Human Genetics Humans MicroRNAs MicroRNAs - genetics Original Paper Positive Regulatory Domain I-Binding Factor 1 Protein Science Proteomics - methods Repressor Proteins - genetics Systems Biology Transcription Factors - genetics Transcriptome - drug effects
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