Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells
The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has flu...
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| Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2016-05, Vol.308 (2), p.659-670 |
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| container_end_page | 670 |
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| container_issue | 2 |
| container_start_page | 659 |
| container_title | Journal of radioanalytical and nuclear chemistry |
| container_volume | 308 |
| creator | Akman, Levent Biber Muftuler, Fazilet Zumrut Bilgi, Ahmet Yurt Kilcar, Ayfer Gokulu, Sevki Goksun Medine, Emin Ilker Terek, Mustafa Cosan |
| description | The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (
131
I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines. |
| doi_str_mv | 10.1007/s10967-015-4472-z |
| format | Article |
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131
I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.</description><subject>Breast cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diagnostic Radiology</subject><subject>Drug delivery systems</subject><subject>Fluorescence</subject><subject>Hadrons</subject><subject>Heavy Ions</subject><subject>Inorganic Chemistry</subject><subject>Nuclear Chemistry</subject><subject>Nuclear Physics</subject><subject>Ovarian cancer</subject><subject>Physical Chemistry</subject><subject>Tracers (Biology)</subject><issn>0236-5731</issn><issn>1588-2780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kc-KFDEQxhtRcFx9AG8BLx7sNf-6O-1tWNbZhQEF9RzS6cpYS08yJpmB3rfyDU3bXgSRQFJUvl9VUV9VvWb0mlHavU-M9m1XU9bUUna8fnxSbVijVM07RZ9WG8pFWzedYM-rFyk9UEp7pcSm-vll9vk7JEwkOGJIiaPxIWW0xBzA5w8kmhEDhhG9yTCSz7e7eVqj_W5box-DnY1HD8SaUzpPkIjxI0FPLphjICNkiMeFxuCXLqUHRjJgMM6hxzyTJX8xEY1_RyzEC1oz_S4yRDApl8K-pMvXNKWX1TNnpgSv_rxX1bePt19v7ur9p939zXZfW6FUrodBOgdScKeE6DiUZUhJuRTM0oFZJQY-dL3kfdOqco-tKRxve8XYSME24qp6u9Y9xfDjDCnrI6ZlAuMhnJNmiqqWMcZ5kb5ZpQczgUbvQo7GLnK9lVL1XPJWFNX1P1TljHBEGzw4LPm_ALYCNoaUIjh9ing0cdaM6sV1vbqui-t6cV0_FoavTCpaf4CoH8I5-rKo_0C_APz8sYc</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Akman, Levent</creator><creator>Biber Muftuler, Fazilet Zumrut</creator><creator>Bilgi, Ahmet</creator><creator>Yurt Kilcar, Ayfer</creator><creator>Gokulu, Sevki Goksun</creator><creator>Medine, Emin Ilker</creator><creator>Terek, Mustafa Cosan</creator><general>Springer Netherlands</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20160501</creationdate><title>Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells</title><author>Akman, Levent ; Biber Muftuler, Fazilet Zumrut ; Bilgi, Ahmet ; Yurt Kilcar, Ayfer ; Gokulu, Sevki Goksun ; Medine, Emin Ilker ; Terek, Mustafa Cosan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-bb4ffe432f83372e1584402431c0b1c83b2b79429568429d6ac38269811d0ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Breast cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diagnostic Radiology</topic><topic>Drug delivery systems</topic><topic>Fluorescence</topic><topic>Hadrons</topic><topic>Heavy Ions</topic><topic>Inorganic Chemistry</topic><topic>Nuclear Chemistry</topic><topic>Nuclear Physics</topic><topic>Ovarian cancer</topic><topic>Physical Chemistry</topic><topic>Tracers (Biology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akman, Levent</creatorcontrib><creatorcontrib>Biber Muftuler, Fazilet Zumrut</creatorcontrib><creatorcontrib>Bilgi, Ahmet</creatorcontrib><creatorcontrib>Yurt Kilcar, Ayfer</creatorcontrib><creatorcontrib>Gokulu, Sevki Goksun</creatorcontrib><creatorcontrib>Medine, Emin Ilker</creatorcontrib><creatorcontrib>Terek, Mustafa Cosan</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akman, Levent</au><au>Biber Muftuler, Fazilet Zumrut</au><au>Bilgi, Ahmet</au><au>Yurt Kilcar, Ayfer</au><au>Gokulu, Sevki Goksun</au><au>Medine, Emin Ilker</au><au>Terek, Mustafa Cosan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells</atitle><jtitle>Journal of radioanalytical and nuclear chemistry</jtitle><stitle>J Radioanal Nucl Chem</stitle><date>2016-05-01</date><risdate>2016</risdate><volume>308</volume><issue>2</issue><spage>659</spage><epage>670</epage><pages>659-670</pages><issn>0236-5731</issn><eissn>1588-2780</eissn><abstract>The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (
131
I) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10967-015-4472-z</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of radioanalytical and nuclear chemistry, 2016-05, Vol.308 (2), p.659-670 |
| issn | 0236-5731 1588-2780 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Breast cancer Chemistry Chemistry and Materials Science Diagnostic Radiology Drug delivery systems Fluorescence Hadrons Heavy Ions Inorganic Chemistry Nuclear Chemistry Nuclear Physics Ovarian cancer Physical Chemistry Tracers (Biology) |
| title | Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells |
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