Clearance of donor cell leukemia by means of graft versus leukemia effect: A case report

Clearance of donor cell leukemia by means of graft versus leukemia effect: A case report

Donor cell leukemia (DCL) is a rare complication of hematopoietic stem cell transplantation (HSCT). Its incidence has been reported between 0.12 and 5%, although the majority of cases are anecdotal. The mechanisms of leukemogenesis in DCL may be distinct from other types of leukemia. Here we describ...

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Veröffentlicht in:Hematology (Luxembourg) 2016-09, Vol.21 (8), p.470-473
Hauptverfasser: Ruiz-Delgado, Guillermo J, León Peña, Andrés A, Gómez-de-León, Andrés, Ruiz-Argüelles, Guillermo J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Female
Graft vs Host Disease - etiology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Leukemia - complications
Tissue Donors
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Beschreibung
Zusammenfassung:Donor cell leukemia (DCL) is a rare complication of hematopoietic stem cell transplantation (HSCT). Its incidence has been reported between 0.12 and 5%, although the majority of cases are anecdotal. The mechanisms of leukemogenesis in DCL may be distinct from other types of leukemia. Here we describe a case of a 27-year-old woman with a diagnosis of biphenotypic acute leukemia who received a HSCT and developed a DCL. We briefly discuss the possible pathogenesis, diagnosis, and treatment of DCL.
ISSN:1607-8454
1607-8454
DOI:10.1080/10245332.2015.1117741