Synthesis and evaluation of benzylisoquinoline derivatives for their inhibition on pancreatic lipase and preadipocyte proliferation

The present study was designed to synthesize and evaluate a series of benzylisoquinoline derivatives. These compounds were synthesized by Bischler-Napieralski cyclization to yield 1-benzyl-3,4-dihydroisoquinolines, and the products were obtained by reductions. All these compounds were identified by...

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Veröffentlicht in:	Chinese journal of natural medicines 2016-05, Vol.14 (5), p.382-390
Hauptverfasser:	TIAN, Feng, LV, Hao-Yu, ZOU, Ji-Long, WANG, Yi, DUAN, Meng-Jun, CHU, Xiao-Qin, LI, Dan, ZHU, Liang, JIANG, Jian-Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocyte proliferation Adipocytes - cytology Adipocytes - drug effects Anti-obesity Benzylisoquinoline alkaloid Benzylisoquinolines - chemical synthesis Benzylisoquinolines - chemistry Benzylisoquinolines - pharmacology Cell Proliferation - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Lipase - antagonists & inhibitors Lipase - metabolism Nelumbo nucifera Pancreatic lipase inhibitor Structure-Activity Relationship
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