Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study

Bisphosphonates and statins are known to have antitumor activities against different types of cancer cell lines. In the present study, we investigated the antiproliferative effects of the combination of zoledronic acid (ZOL), a bisphophosphonate, and fluvastatin (FLU), a statin, in vitro on two type...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2016/08/01, Vol.39(8), pp.1238-1246
Hauptverfasser:	Elsayed, Mahitab, Kobayashi, Daisuke, Kubota, Toshio, Matsunaga, Naoya, Murata, Ryusei, Yoshizawa, Yuko, Watanabe, Natsuki, Matsuura, Tohru, Tsurudome, Yuya, Ogino, Takashi, Ohdo, Shigehiro, Shimazoe, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - pharmacology Antineoplastic Agents - pharmacology Antioxidants - pharmacology Cell Line, Tumor Cell Proliferation - drug effects combination treatment Diphosphonates - pharmacology Fatty Acids, Monounsaturated - pharmacology fluvastatin Humans Imidazoles - pharmacology Indoles - pharmacology Mevalonic Acid - metabolism pancreatic cancer Pancreatic Neoplasms - metabolism Polyisoprenyl Phosphates - metabolism ras Proteins - metabolism rhoA GTP-Binding Protein - metabolism synergistic zoledronic acid
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