Copper Exchange and Redox Activity of a Prototypical 8‑Hydroxyquinoline: Implications for Therapeutic Chelation

The N-truncated β-amyloid (Aβ) isoform Aβ4–x is known to bind Cu2+ via a redox-silent ATCUN motif with a conditional K d = 30 fM at pH 7.4. This study characterizes the Cu2+ interactions and redox activity of Aβ x–16 (x = 1, 4) and 2-[(dimethylamino)-methyl-8-hydroxyquinoline, a terdentate 8-hydroxy...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Inorganic chemistry 2016-08, Vol.55 (15), p.7317-7319
Hauptverfasser:	Mital, Mariusz, Zawisza, Izabela A, Wiloch, Magdalena Z, Wawrzyniak, Urszula E, Kenche, Vijaya, Wróblewski, Wojciech, Bal, Wojciech, Drew, Simon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Copper - chemistry Copper - metabolism Electron Spin Resonance Spectroscopy Humans Kinetics Oxidation-Reduction Oxyquinoline - chemistry Quinolines - chemistry Quinolines - metabolism Reactive Oxygen Species - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!