Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen
Abstract Purpose To correlate partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen (RDR). Design Observational case series with controls of similar age Methods Twenty eyes from 18 patients with RDR (mean age 75.8 years) and 20 eyes f...
Gespeichert in:
| Veröffentlicht in: | American journal of ophthalmology 2016-08, Vol.168, p.52-61 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | |
| container_start_page | 52 |
| container_title | American journal of ophthalmology |
| container_volume | 168 |
| creator | Steinberg, Julia S Saßmannshausen, Marlene Fleckenstein, Monika Fimmers, Rolf Oishi, Akio Holz, Frank G Schmitz-Valckenberg, Steffen |
| description | Abstract Purpose To correlate partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen (RDR). Design Observational case series with controls of similar age Methods Twenty eyes from 18 patients with RDR (mean age 75.8 years) and 20 eyes from 20 healthy controls (mean age 75.5 years) were included. Scotopic and mesopic fundus-controlled perimetry was performed in patients. The localized partial outer retinal thickness at the site of test stimuli was determined as the distance between the outer border of the outer plexiform layer and the inner border of the ellipsoid zone and topographically corrected according to measurements in controls. Results The mean partial outer retinal thickness in patients was 65.8μm over areas with RDR and 76.4μm (p |
| doi_str_mv | 10.1016/j.ajo.2016.04.025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808377182</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002939416302008</els_id><sourcerecordid>1898092837</sourcerecordid><originalsourceid>FETCH-LOGICAL-a459t-9134aac1e3cad9d443aa5b3de8d734f6b26dceae4686915a22fcdf7e0453286e3</originalsourceid><addsrcrecordid>eNp9ks2KFDEUhYMoTs_oA7iRgBs3VeavfoIgSKOjMOBCXYd0cotJTTppk5TSL-Bzm7JbhVm4yr3w3RPOPRehZ5S0lND-1dzqObasli0RLWHdA7Sh4yAbOkr6EG0IIayRXIoLdJnzXNt-EMNjdMEG2nPGuw36uY0pgdfFxYDjhA86Fac9jkuBhBMUF2pXbp25C5Az_uHKLc4mlnhwButg8R7y73pagl1yY2IoKXoPFh8guT2UdMQuVOHiIJSzwipsFq8TtmnJEJ6gR5P2GZ6e3yv09f27L9sPzc2n64_btzeNFp0sjaRcaG0ocKOttEJwrbsdtzDagYup37HeGtAg-rGXtNOMTcZOAxDRcTb2wK_Qy5PuIcVvC-Si9i4b8F4HiEtWdCQjHwY6soq-uIfOcUl1GyslRyJZJStFT5RJMecEkzpU0zodFSVqDUnNqoak1pAUEaqGVGeen5WX3R7s34k_qVTg9QmAuorvDpLKpi7PgHUJTFE2uv_Kv7k3bbwLzmh_B0fI_1yozBRRn9crWY-kfk4Yqf5_AR2oumE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898092837</pqid></control><display><type>article</type><title>Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Steinberg, Julia S ; Saßmannshausen, Marlene ; Fleckenstein, Monika ; Fimmers, Rolf ; Oishi, Akio ; Holz, Frank G ; Schmitz-Valckenberg, Steffen</creator><creatorcontrib>Steinberg, Julia S ; Saßmannshausen, Marlene ; Fleckenstein, Monika ; Fimmers, Rolf ; Oishi, Akio ; Holz, Frank G ; Schmitz-Valckenberg, Steffen</creatorcontrib><description>Abstract Purpose To correlate partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen (RDR). Design Observational case series with controls of similar age Methods Twenty eyes from 18 patients with RDR (mean age 75.8 years) and 20 eyes from 20 healthy controls (mean age 75.5 years) were included. Scotopic and mesopic fundus-controlled perimetry was performed in patients. The localized partial outer retinal thickness at the site of test stimuli was determined as the distance between the outer border of the outer plexiform layer and the inner border of the ellipsoid zone and topographically corrected according to measurements in controls. Results The mean partial outer retinal thickness in patients was 65.8μm over areas with RDR and 76.4μm (p<0.0001) over non-affected retinal areas. Mesopic and scotopic sensitivity were reduced corresponding to areas with RDR (mean scotopic 12.8dB and mean mesopic 17.2dB ) as compared to non-affected retinal areas (18.2dB and 18.4dB) (p<0.001, p=0.001). On average a reduction of partial outer retinal thickness by 1μm was associated with a decrease of scotopic function of 0.96dB. Conclusions The extent of outer retinal thinning in the presence of RDR is spatially associated with the extent of impairment in scotopic retinal function, indicating a direct structural-functional correlation of structural changes to loss of rod function. High-resolution retinal imaging in combination with scotopic fundus-controlled perimetry allows for a more refined structure-function correlation in diseases with a presumed higher vulnerability of rod compared with cone function.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2016.04.025</identifier><identifier>PMID: 27163235</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptation ; Age ; Aged ; Aged, 80 and over ; Classification ; Female ; Humans ; Lasers ; Macular degeneration ; Male ; Medical imaging ; Mesopic Vision - physiology ; Middle Aged ; Night Vision - physiology ; Ophthalmology ; Photoreceptors ; Retina ; Retina - pathology ; Retinal Drusen - pathology ; Retinal Drusen - physiopathology ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Visual Field Tests ; Visual Fields - physiology</subject><ispartof>American journal of ophthalmology, 2016-08, Vol.168, p.52-61</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 1, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a459t-9134aac1e3cad9d443aa5b3de8d734f6b26dceae4686915a22fcdf7e0453286e3</citedby><cites>FETCH-LOGICAL-a459t-9134aac1e3cad9d443aa5b3de8d734f6b26dceae4686915a22fcdf7e0453286e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2016.04.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27163235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinberg, Julia S</creatorcontrib><creatorcontrib>Saßmannshausen, Marlene</creatorcontrib><creatorcontrib>Fleckenstein, Monika</creatorcontrib><creatorcontrib>Fimmers, Rolf</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Holz, Frank G</creatorcontrib><creatorcontrib>Schmitz-Valckenberg, Steffen</creatorcontrib><title>Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Abstract Purpose To correlate partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen (RDR). Design Observational case series with controls of similar age Methods Twenty eyes from 18 patients with RDR (mean age 75.8 years) and 20 eyes from 20 healthy controls (mean age 75.5 years) were included. Scotopic and mesopic fundus-controlled perimetry was performed in patients. The localized partial outer retinal thickness at the site of test stimuli was determined as the distance between the outer border of the outer plexiform layer and the inner border of the ellipsoid zone and topographically corrected according to measurements in controls. Results The mean partial outer retinal thickness in patients was 65.8μm over areas with RDR and 76.4μm (p<0.0001) over non-affected retinal areas. Mesopic and scotopic sensitivity were reduced corresponding to areas with RDR (mean scotopic 12.8dB and mean mesopic 17.2dB ) as compared to non-affected retinal areas (18.2dB and 18.4dB) (p<0.001, p=0.001). On average a reduction of partial outer retinal thickness by 1μm was associated with a decrease of scotopic function of 0.96dB. Conclusions The extent of outer retinal thinning in the presence of RDR is spatially associated with the extent of impairment in scotopic retinal function, indicating a direct structural-functional correlation of structural changes to loss of rod function. High-resolution retinal imaging in combination with scotopic fundus-controlled perimetry allows for a more refined structure-function correlation in diseases with a presumed higher vulnerability of rod compared with cone function.</description><subject>Adaptation</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Classification</subject><subject>Female</subject><subject>Humans</subject><subject>Lasers</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mesopic Vision - physiology</subject><subject>Middle Aged</subject><subject>Night Vision - physiology</subject><subject>Ophthalmology</subject><subject>Photoreceptors</subject><subject>Retina</subject><subject>Retina - pathology</subject><subject>Retinal Drusen - pathology</subject><subject>Retinal Drusen - physiopathology</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests</subject><subject>Visual Fields - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2KFDEUhYMoTs_oA7iRgBs3VeavfoIgSKOjMOBCXYd0cotJTTppk5TSL-Bzm7JbhVm4yr3w3RPOPRehZ5S0lND-1dzqObasli0RLWHdA7Sh4yAbOkr6EG0IIayRXIoLdJnzXNt-EMNjdMEG2nPGuw36uY0pgdfFxYDjhA86Fac9jkuBhBMUF2pXbp25C5Az_uHKLc4mlnhwButg8R7y73pagl1yY2IoKXoPFh8guT2UdMQuVOHiIJSzwipsFq8TtmnJEJ6gR5P2GZ6e3yv09f27L9sPzc2n64_btzeNFp0sjaRcaG0ocKOttEJwrbsdtzDagYup37HeGtAg-rGXtNOMTcZOAxDRcTb2wK_Qy5PuIcVvC-Si9i4b8F4HiEtWdCQjHwY6soq-uIfOcUl1GyslRyJZJStFT5RJMecEkzpU0zodFSVqDUnNqoak1pAUEaqGVGeen5WX3R7s34k_qVTg9QmAuorvDpLKpi7PgHUJTFE2uv_Kv7k3bbwLzmh_B0fI_1yozBRRn9crWY-kfk4Yqf5_AR2oumE</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Steinberg, Julia S</creator><creator>Saßmannshausen, Marlene</creator><creator>Fleckenstein, Monika</creator><creator>Fimmers, Rolf</creator><creator>Oishi, Akio</creator><creator>Holz, Frank G</creator><creator>Schmitz-Valckenberg, Steffen</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen</title><author>Steinberg, Julia S ; Saßmannshausen, Marlene ; Fleckenstein, Monika ; Fimmers, Rolf ; Oishi, Akio ; Holz, Frank G ; Schmitz-Valckenberg, Steffen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a459t-9134aac1e3cad9d443aa5b3de8d734f6b26dceae4686915a22fcdf7e0453286e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adaptation</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Classification</topic><topic>Female</topic><topic>Humans</topic><topic>Lasers</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Mesopic Vision - physiology</topic><topic>Middle Aged</topic><topic>Night Vision - physiology</topic><topic>Ophthalmology</topic><topic>Photoreceptors</topic><topic>Retina</topic><topic>Retina - pathology</topic><topic>Retinal Drusen - pathology</topic><topic>Retinal Drusen - physiopathology</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinberg, Julia S</creatorcontrib><creatorcontrib>Saßmannshausen, Marlene</creatorcontrib><creatorcontrib>Fleckenstein, Monika</creatorcontrib><creatorcontrib>Fimmers, Rolf</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Holz, Frank G</creatorcontrib><creatorcontrib>Schmitz-Valckenberg, Steffen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinberg, Julia S</au><au>Saßmannshausen, Marlene</au><au>Fleckenstein, Monika</au><au>Fimmers, Rolf</au><au>Oishi, Akio</au><au>Holz, Frank G</au><au>Schmitz-Valckenberg, Steffen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>168</volume><spage>52</spage><epage>61</epage><pages>52-61</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>Abstract Purpose To correlate partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen (RDR). Design Observational case series with controls of similar age Methods Twenty eyes from 18 patients with RDR (mean age 75.8 years) and 20 eyes from 20 healthy controls (mean age 75.5 years) were included. Scotopic and mesopic fundus-controlled perimetry was performed in patients. The localized partial outer retinal thickness at the site of test stimuli was determined as the distance between the outer border of the outer plexiform layer and the inner border of the ellipsoid zone and topographically corrected according to measurements in controls. Results The mean partial outer retinal thickness in patients was 65.8μm over areas with RDR and 76.4μm (p<0.0001) over non-affected retinal areas. Mesopic and scotopic sensitivity were reduced corresponding to areas with RDR (mean scotopic 12.8dB and mean mesopic 17.2dB ) as compared to non-affected retinal areas (18.2dB and 18.4dB) (p<0.001, p=0.001). On average a reduction of partial outer retinal thickness by 1μm was associated with a decrease of scotopic function of 0.96dB. Conclusions The extent of outer retinal thinning in the presence of RDR is spatially associated with the extent of impairment in scotopic retinal function, indicating a direct structural-functional correlation of structural changes to loss of rod function. High-resolution retinal imaging in combination with scotopic fundus-controlled perimetry allows for a more refined structure-function correlation in diseases with a presumed higher vulnerability of rod compared with cone function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27163235</pmid><doi>10.1016/j.ajo.2016.04.025</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9394 |
| ispartof | American journal of ophthalmology, 2016-08, Vol.168, p.52-61 |
| issn | 0002-9394 1879-1891 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808377182 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adaptation Age Aged Aged, 80 and over Classification Female Humans Lasers Macular degeneration Male Medical imaging Mesopic Vision - physiology Middle Aged Night Vision - physiology Ophthalmology Photoreceptors Retina Retina - pathology Retinal Drusen - pathology Retinal Drusen - physiopathology Tomography, Optical Coherence Visual Acuity - physiology Visual Field Tests Visual Fields - physiology |
| title | Correlation of partial outer retinal thickness with scotopic and mesopic fundus-controlled perimetry in patients with reticular drusen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T08%3A11%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20partial%20outer%20retinal%20thickness%20with%20scotopic%20and%20mesopic%20fundus-controlled%20perimetry%20in%20patients%20with%20reticular%20drusen&rft.jtitle=American%20journal%20of%20ophthalmology&rft.au=Steinberg,%20Julia%20S&rft.date=2016-08-01&rft.volume=168&rft.spage=52&rft.epage=61&rft.pages=52-61&rft.issn=0002-9394&rft.eissn=1879-1891&rft_id=info:doi/10.1016/j.ajo.2016.04.025&rft_dat=%3Cproquest_cross%3E1898092837%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1898092837&rft_id=info:pmid/27163235&rft_els_id=1_s2_0_S0002939416302008&rfr_iscdi=true |