Induction of brain‐derived neurotrophic factor by convulsant drugs in the rat brain: involvement of region‐specific voltage‐dependent calcium channels

A high level of hippocampal brain‐derived neurotrophic factor (BDNF) in normally aged as compared with young rats suggests that it is important to maintain a considerable level of hippocampal BDNF during aging in order to keep normal hippocampal functions. To elucidate possible mechanisms of endogen...

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Veröffentlicht in:	Journal of neurochemistry 2001-04, Vol.77 (1), p.71-83
Hauptverfasser:	Katoh‐Semba, Ritsuko, Takeuchi, Ikuo K., Inaguma, Yutaka, Ichisaka, Satoshi, Hata, Yoshio, Tsumoto, Tadaharu, Iwai, Miwako, Mikoshiba, Katsuhiko, Kato, Kanefusa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain-Derived Neurotrophic Factor - analysis Brain-Derived Neurotrophic Factor - metabolism brain‐derived neurotrophic factor Calcium Channel Agonists - pharmacology Calcium Channel Blockers - pharmacology Calcium Channels - deficiency Calcium Channels - genetics Calcium Channels - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Convulsants - pharmacology convulsion Cyclic AMP Response Element-Binding Protein - metabolism Dose-Response Relationship, Drug Entorhinal Cortex - drug effects Entorhinal Cortex - metabolism Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Inositol 1,4,5-Trisphosphate Receptors kainic acid Male Mice Mice, Knockout Neocortex - drug effects Neocortex - metabolism Organ Specificity - drug effects Phosphorylation - drug effects rat Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Seizures - chemically induced Survival Rate Vertebrates: nervous system and sense organs voltage‐dependent calcium channel
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