Developmental evaluation of a potential non-steroidal estrogen: triclosan
Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A). Japanese medaka f...
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| Veröffentlicht in: | Marine environmental research 2000-07, Vol.50 (1), p.153-156 |
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| creator | Foran, C.M Bennett, E.R Benson, W.H |
| description | Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A). Japanese medaka fry (
Oryzias latipes) were exposed for 14 days beginning 2 days post-hatch to triclosan (100, 10, 1 μg/l), 17-β estradiol (E2; 1 μg/l), or a solvent control (ethanol). Two months post-exposure, the phenotypic sex of each adult was assessed visually using sexually dimorphic fin shape and size. The proportion of females in each group was similar for triclosan-exposed animals and solvent-treated controls (ethanol 53%, 1 ppb 58%, 10 ppb 45%, 100 ppb 36%) although E2 treatment did produce 92% female adults. Sexually dimorphic fin traits were quantified to look for potential effects of triclosan and E2 on the development of secondary sexual characters. These results do not support the hypothesis that triclosan is potently estrogenic. However, changes in fin length and non-significant trends in sex ratio suggest triclosan is potentially weakly androgenic. |
| doi_str_mv | 10.1016/S0141-1136(00)00080-5 |
| format | Article |
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Oryzias latipes) were exposed for 14 days beginning 2 days post-hatch to triclosan (100, 10, 1 μg/l), 17-β estradiol (E2; 1 μg/l), or a solvent control (ethanol). Two months post-exposure, the phenotypic sex of each adult was assessed visually using sexually dimorphic fin shape and size. The proportion of females in each group was similar for triclosan-exposed animals and solvent-treated controls (ethanol 53%, 1 ppb 58%, 10 ppb 45%, 100 ppb 36%) although E2 treatment did produce 92% female adults. Sexually dimorphic fin traits were quantified to look for potential effects of triclosan and E2 on the development of secondary sexual characters. These results do not support the hypothesis that triclosan is potently estrogenic. However, changes in fin length and non-significant trends in sex ratio suggest triclosan is potentially weakly androgenic.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Anti-Infective Agents, Local - toxicity</subject><subject>Antibacterial</subject><subject>antibacterial agents</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Effects-fish</subject><subject>endocrine disruptors</subject><subject>endocrine system</subject><subject>Estradiol - pharmacology</subject><subject>estrogens</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Anti-Infective Agents, Local - toxicity</topic><topic>Antibacterial</topic><topic>antibacterial agents</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Effects-fish</topic><topic>endocrine disruptors</topic><topic>endocrine system</topic><topic>Estradiol - pharmacology</topic><topic>estrogens</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Marine</topic><topic>Oryzias - metabolism</topic><topic>Oryzias latipes</topic><topic>Phenotype</topic><topic>Reproductive cycle</topic><topic>Secondary sexual characters</topic><topic>Sex Characteristics</topic><topic>Sex Ratio</topic><topic>Sexual Maturation - drug effects</topic><topic>triclosan</topic><topic>Triclosan - toxicity</topic><topic>Wastewater</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foran, C.M</creatorcontrib><creatorcontrib>Bennett, E.R</creatorcontrib><creatorcontrib>Benson, W.H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><jtitle>Marine environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foran, C.M</au><au>Bennett, E.R</au><au>Benson, W.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental evaluation of a potential non-steroidal estrogen: triclosan</atitle><jtitle>Marine environmental research</jtitle><addtitle>Mar Environ Res</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>50</volume><issue>1</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0141-1136</issn><eissn>1879-0291</eissn><abstract>Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A). Japanese medaka fry (
Oryzias latipes) were exposed for 14 days beginning 2 days post-hatch to triclosan (100, 10, 1 μg/l), 17-β estradiol (E2; 1 μg/l), or a solvent control (ethanol). Two months post-exposure, the phenotypic sex of each adult was assessed visually using sexually dimorphic fin shape and size. The proportion of females in each group was similar for triclosan-exposed animals and solvent-treated controls (ethanol 53%, 1 ppb 58%, 10 ppb 45%, 100 ppb 36%) although E2 treatment did produce 92% female adults. Sexually dimorphic fin traits were quantified to look for potential effects of triclosan and E2 on the development of secondary sexual characters. These results do not support the hypothesis that triclosan is potently estrogenic. However, changes in fin length and non-significant trends in sex ratio suggest triclosan is potentially weakly androgenic.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11460682</pmid><doi>10.1016/S0141-1136(00)00080-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | Marine environmental research, 2000-07, Vol.50 (1), p.153-156 |
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| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Anti-Infective Agents, Local - toxicity Antibacterial antibacterial agents Applied ecology Biological and medical sciences Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Effects-fish endocrine disruptors endocrine system Estradiol - pharmacology estrogens Female Fundamental and applied biological sciences. Psychology Male Marine Oryzias - metabolism Oryzias latipes Phenotype Reproductive cycle Secondary sexual characters Sex Characteristics Sex Ratio Sexual Maturation - drug effects triclosan Triclosan - toxicity Wastewater Water Pollutants, Chemical - toxicity |
| title | Developmental evaluation of a potential non-steroidal estrogen: triclosan |
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