Exposure to environmentally relevant concentrations of different nonylphenol formulations in Japanese medaka
The time course of exposure to p-nonylphenol (NP) from two different sources was compared to equalivent exposures of 17-β-estradiol (E2) and a solvent control (ethanol; EtOH). Japanese medaka were exposed for 4 days to a nominal concentration of 20 μg/l of either NP-I (Schenectady International, Inc...
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| Veröffentlicht in: | Marine environmental research 2000-07, Vol.50 (1), p.135-139 |
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| creator | Foran, C.M Bennett, E.R Benson, W.H |
| description | The time course of exposure to
p-nonylphenol (NP) from two different sources was compared to equalivent exposures of 17-β-estradiol (E2) and a solvent control (ethanol; EtOH). Japanese medaka were exposed for 4 days to a nominal concentration of 20 μg/l of either NP-I (Schenectady International, Inc.), NP-II (Aldrich), or E2, and were then placed in untreated water for 5 days. Tissue samples were taken at two time points during the 4-day exposure and two time points during the 5 days following exposure. Liver homogenates were analyzed using a western blot to detect vitellogenin (VTG) and quantified by measuring the optical density for each lane. Preliminary results indicate that E2 significantly increased VTG staining above the level observed in EtOH-treated controls for both males and females. A two-way analysis of variance (ANOVA) indicates that NP from both sources, as well as E2, significantly increased VTG staining in males (ANOVA,
n=48,
P |
| doi_str_mv | 10.1016/S0141-1136(00)00115-X |
| format | Article |
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p-nonylphenol (NP) from two different sources was compared to equalivent exposures of 17-β-estradiol (E2) and a solvent control (ethanol; EtOH). Japanese medaka were exposed for 4 days to a nominal concentration of 20 μg/l of either NP-I (Schenectady International, Inc.), NP-II (Aldrich), or E2, and were then placed in untreated water for 5 days. Tissue samples were taken at two time points during the 4-day exposure and two time points during the 5 days following exposure. Liver homogenates were analyzed using a western blot to detect vitellogenin (VTG) and quantified by measuring the optical density for each lane. Preliminary results indicate that E2 significantly increased VTG staining above the level observed in EtOH-treated controls for both males and females. A two-way analysis of variance (ANOVA) indicates that NP from both sources, as well as E2, significantly increased VTG staining in males (ANOVA,
n=48,
P<0.001; Tukey pairwise tests, all
P<0.008). A significant increase in VTG was observed in E2-treated males and females the first day following transfer into toxicant-free water (two-way ANOVAs, both
n=48,
P<0.003; Tukey pairwise tests, all
P<0.019). If confirmed, this extended response observed for low-level exposures may represent a significant factor for sampling scenarios following pulsitile exposure.</description><identifier>ISSN: 0141-1136</identifier><identifier>EISSN: 1879-0291</identifier><identifier>DOI: 10.1016/S0141-1136(00)00115-X</identifier><identifier>PMID: 11460679</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Chromatography, Gas - veterinary ; Dose-Response Relationship, Drug ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Estradiol - administration & dosage ; Estradiol - pharmacology ; estradiol-17b ; Female ; Fundamental and applied biological sciences. Psychology ; Liver - drug effects ; Liver - metabolism ; Male ; Marine ; nonylphenol ; Oryzias - metabolism ; Oryzias latipes ; Phenols - administration & dosage ; Phenols - pharmacology ; vitellogenin ; Vitellogenins - analysis ; Water Pollutants, Chemical - administration & dosage ; Water Pollutants, Chemical - pharmacology</subject><ispartof>Marine environmental research, 2000-07, Vol.50 (1), p.135-139</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-a94b5badf2220e0dd59d1c0452596907c091f9c72c9428135757647c93a06d0f3</citedby><cites>FETCH-LOGICAL-c482t-a94b5badf2220e0dd59d1c0452596907c091f9c72c9428135757647c93a06d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0141-1136(00)00115-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3538,23912,23913,25122,27906,27907,45977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=884788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11460679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foran, C.M</creatorcontrib><creatorcontrib>Bennett, E.R</creatorcontrib><creatorcontrib>Benson, W.H</creatorcontrib><title>Exposure to environmentally relevant concentrations of different nonylphenol formulations in Japanese medaka</title><title>Marine environmental research</title><addtitle>Mar Environ Res</addtitle><description>The time course of exposure to
p-nonylphenol (NP) from two different sources was compared to equalivent exposures of 17-β-estradiol (E2) and a solvent control (ethanol; EtOH). Japanese medaka were exposed for 4 days to a nominal concentration of 20 μg/l of either NP-I (Schenectady International, Inc.), NP-II (Aldrich), or E2, and were then placed in untreated water for 5 days. Tissue samples were taken at two time points during the 4-day exposure and two time points during the 5 days following exposure. Liver homogenates were analyzed using a western blot to detect vitellogenin (VTG) and quantified by measuring the optical density for each lane. Preliminary results indicate that E2 significantly increased VTG staining above the level observed in EtOH-treated controls for both males and females. A two-way analysis of variance (ANOVA) indicates that NP from both sources, as well as E2, significantly increased VTG staining in males (ANOVA,
n=48,
P<0.001; Tukey pairwise tests, all
P<0.008). A significant increase in VTG was observed in E2-treated males and females the first day following transfer into toxicant-free water (two-way ANOVAs, both
n=48,
P<0.003; Tukey pairwise tests, all
P<0.019). If confirmed, this extended response observed for low-level exposures may represent a significant factor for sampling scenarios following pulsitile exposure.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas - veterinary</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - pharmacology</subject><subject>estradiol-17b</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Marine</subject><subject>nonylphenol</subject><subject>Oryzias - metabolism</subject><subject>Oryzias latipes</subject><subject>Phenols - administration & dosage</subject><subject>Phenols - pharmacology</subject><subject>vitellogenin</subject><subject>Vitellogenins - analysis</subject><subject>Water Pollutants, Chemical - administration & dosage</subject><subject>Water Pollutants, Chemical - pharmacology</subject><issn>0141-1136</issn><issn>1879-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c9rFTEQB_Agin2t_glKQBA9rM7kbTabk0hp_UHBgwq9hbxsgtFssia7D99_b9q31GM9BYbPZIb5EvIM4Q0Cdm-_ArbYIG67VwCvARB5c_2AbLAXsgEm8SHZ3JETclrKTwDgAvljcoLYdtAJuSHh4s-UypItnRO1ce9ziqONsw7hQLMNdq_jTE2Kphaznn2KhSZHB--czbVGY4qHMP2wMQXqUh6XsCof6Wc96WiLpaMd9C_9hDxyOhT7dH3PyPfLi2_nH5urLx8-nb-_akzbs7nRst3xnR4cYwwsDAOXAxpoOeOykyAMSHTSCGZky3rccsFF1wojtxq6Adz2jLw8_jvl9HuxZVajL8aGUJdJS1HYQ8-YkP8D60CO98OWcyG7rkJ-hCanUrJ1asp-1PmgENRNcOo2OHWTigJQt8Gp69r3fB2w7Oqx_nWtSVXwYgW6GB1c1tH4cuf6vhV9X9W7o7L1vHtvsyrG2xre4LM1sxqSv2eRv7nstcE</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Foran, C.M</creator><creator>Bennett, E.R</creator><creator>Benson, W.H</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TN</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>H97</scope></search><sort><creationdate>20000701</creationdate><title>Exposure to environmentally relevant concentrations of different nonylphenol formulations in Japanese medaka</title><author>Foran, C.M ; Bennett, E.R ; Benson, W.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-a94b5badf2220e0dd59d1c0452596907c091f9c72c9428135757647c93a06d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas - veterinary</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - pharmacology</topic><topic>estradiol-17b</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Marine</topic><topic>nonylphenol</topic><topic>Oryzias - metabolism</topic><topic>Oryzias latipes</topic><topic>Phenols - administration & dosage</topic><topic>Phenols - pharmacology</topic><topic>vitellogenin</topic><topic>Vitellogenins - analysis</topic><topic>Water Pollutants, Chemical - administration & dosage</topic><topic>Water Pollutants, Chemical - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foran, C.M</creatorcontrib><creatorcontrib>Bennett, E.R</creatorcontrib><creatorcontrib>Benson, W.H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><jtitle>Marine environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foran, C.M</au><au>Bennett, E.R</au><au>Benson, W.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to environmentally relevant concentrations of different nonylphenol formulations in Japanese medaka</atitle><jtitle>Marine environmental research</jtitle><addtitle>Mar Environ Res</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>50</volume><issue>1</issue><spage>135</spage><epage>139</epage><pages>135-139</pages><issn>0141-1136</issn><eissn>1879-0291</eissn><abstract>The time course of exposure to
p-nonylphenol (NP) from two different sources was compared to equalivent exposures of 17-β-estradiol (E2) and a solvent control (ethanol; EtOH). Japanese medaka were exposed for 4 days to a nominal concentration of 20 μg/l of either NP-I (Schenectady International, Inc.), NP-II (Aldrich), or E2, and were then placed in untreated water for 5 days. Tissue samples were taken at two time points during the 4-day exposure and two time points during the 5 days following exposure. Liver homogenates were analyzed using a western blot to detect vitellogenin (VTG) and quantified by measuring the optical density for each lane. Preliminary results indicate that E2 significantly increased VTG staining above the level observed in EtOH-treated controls for both males and females. A two-way analysis of variance (ANOVA) indicates that NP from both sources, as well as E2, significantly increased VTG staining in males (ANOVA,
n=48,
P<0.001; Tukey pairwise tests, all
P<0.008). A significant increase in VTG was observed in E2-treated males and females the first day following transfer into toxicant-free water (two-way ANOVAs, both
n=48,
P<0.003; Tukey pairwise tests, all
P<0.019). If confirmed, this extended response observed for low-level exposures may represent a significant factor for sampling scenarios following pulsitile exposure.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11460679</pmid><doi>10.1016/S0141-1136(00)00115-X</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Chromatography, Gas - veterinary Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Estradiol - administration & dosage Estradiol - pharmacology estradiol-17b Female Fundamental and applied biological sciences. Psychology Liver - drug effects Liver - metabolism Male Marine nonylphenol Oryzias - metabolism Oryzias latipes Phenols - administration & dosage Phenols - pharmacology vitellogenin Vitellogenins - analysis Water Pollutants, Chemical - administration & dosage Water Pollutants, Chemical - pharmacology |
| title | Exposure to environmentally relevant concentrations of different nonylphenol formulations in Japanese medaka |
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