Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different Hosts
The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and an...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-09, Vol.341 (6153), p.1514-1517 |
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| creator | Mather, A. E. Reid, S. W. J. Maskell, D. J. Parkhill, J. Fookes, M. C. Harris, S. R. Brown, D. J. Coia, J. E. Mulvey, M. R. Gilmour, M. W. Petrovska, L. de Pinna, E. Kuroda, M. Akiba, M. Izumiya, H. Connor, T. R. Suchard, M. A. Lemey, P. Mellor, D. J. Haydon, D. T. Thomson, N. R. |
| description | The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance. |
| doi_str_mv | 10.1126/science.1240578 |
| format | Article |
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E.</creatorcontrib><creatorcontrib>Reid, S. W. J.</creatorcontrib><creatorcontrib>Maskell, D. J.</creatorcontrib><creatorcontrib>Parkhill, J.</creatorcontrib><creatorcontrib>Fookes, M. C.</creatorcontrib><creatorcontrib>Harris, S. R.</creatorcontrib><creatorcontrib>Brown, D. J.</creatorcontrib><creatorcontrib>Coia, J. E.</creatorcontrib><creatorcontrib>Mulvey, M. R.</creatorcontrib><creatorcontrib>Gilmour, M. W.</creatorcontrib><creatorcontrib>Petrovska, L.</creatorcontrib><creatorcontrib>de Pinna, E.</creatorcontrib><creatorcontrib>Kuroda, M.</creatorcontrib><creatorcontrib>Akiba, M.</creatorcontrib><creatorcontrib>Izumiya, H.</creatorcontrib><creatorcontrib>Connor, T. R.</creatorcontrib><creatorcontrib>Suchard, M. A.</creatorcontrib><creatorcontrib>Lemey, P.</creatorcontrib><creatorcontrib>Mellor, D. J.</creatorcontrib><creatorcontrib>Haydon, D. T.</creatorcontrib><creatorcontrib>Thomson, N. R.</creatorcontrib><title>Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different Hosts</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Disease transmission</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Epidemics</subject><subject>Farms</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Host-Pathogen Interactions</subject><subject>Human</subject><subject>Humans</subject><subject>Infections</subject><subject>Livestock</subject><subject>Molecular Sequence Data</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Salmonella</subject><subject>Salmonella Infections - epidemiology</subject><subject>Salmonella Infections - microbiology</subject><subject>Salmonella Infections, Animal - epidemiology</subject><subject>Salmonella Infections, Animal - microbiology</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium - classification</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><subject>Sourcing</subject><subject>Zoonoses</subject><subject>Zoonoses - microbiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0btv2zAQB2AiaBA7j7lTAwFdssi5I8WHxiLOC0hRoPWuUBQV09DDIcUh_31p2PHQqQABDvfxwLsfIV8RFohU3Abj7GDsAmkBXKoTMkcoeV5SYF_IHICJXIHkM3IewgYg1Up2RmZJMyhKnJPXpQuTG96iC2tddza737rG9s6EbGyzn7GbXOPjW_7bhgT1MGV_dNePg-06na0-tmvXR-9iny1XCEXmhmzp2tZ6m-TTGKZwSU5b3QV7dbgvyOrhfnX3lL_8eny--_GSGw4w5RwpFbyWWsk2nQYEq7lS0tSNYLRWDKlk0MjG6JIprShwLNEWVAgwlLMLcrNvu_Xje7RhqnoXzO6Xgx1jqFCBSgtD-A_KOYpCUEUT_f4P3YzRD2mOCgsmd1KKpG73yvgxBG_bautdr_1HhVDtYqoOMVWHmNKL60PfWPe2OfrPXBL4tgebMI3-WE_jYlmgYH8B6OSWlg</recordid><startdate>20130927</startdate><enddate>20130927</enddate><creator>Mather, A. 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| ispartof | Science (American Association for the Advancement of Science), 2013-09, Vol.341 (6153), p.1514-1517 |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animals Antibiotics Bacteria Disease transmission Drug resistance Drug Resistance, Multiple, Bacterial - genetics Epidemics Farms Genome, Bacterial Genomes Host-Pathogen Interactions Human Humans Infections Livestock Molecular Sequence Data Phylogenetics Phylogeny Salmonella Salmonella Infections - epidemiology Salmonella Infections - microbiology Salmonella Infections, Animal - epidemiology Salmonella Infections, Animal - microbiology Salmonella typhimurium Salmonella typhimurium - classification Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Sourcing Zoonoses Zoonoses - microbiology |
| title | Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different Hosts |
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