Simultaneous determination of shanzhiside methyl ester, 8-O-acetylshan- zhiside methyl ester and luteolin-7-O-β-d-glucopyranoside in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Lamiophlomis rotata Pill

•Simultaneous determination of three bioactive constituents in rat plasma.•Pharmacokinetic study of three components by UPLC–MS/MS.•The first report on pharmacokinetic study of Lamiophlomis rotata Pill by UPLC–MS/MS. A rapid, sensitive and specific ultra performance liquid chromatography-tandem mass...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2016-05, Vol.1020, p.62-66
Hauptverfasser:	Chen, Jing, Wang, Yang, Liang, Xinlei, Sun, Tingting, Luo, Jinghan, Guo, Xingjie, Zhao, Longshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Chromatography Chromatography, High Pressure Liquid - methods Drug Stability Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics Esters Glucosides - blood Glucosides - chemistry Glucosides - pharmacokinetics Lamiophlomis rotata pill Linear Models Linearity Liquids Luteolin - blood Luteolin - chemistry Luteolin - pharmacokinetics Mass spectrometry Pharmacokinetics Pharmacology Pills Rat plasma Rats Reproducibility of Results Sensitivity and Specificity Tandem Mass Spectrometry - methods UPLC–MS/MS
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