Determination of residual fipronil in chicken egg and muscle by LC–MS/MS
•Fipronil residues in chicken egg and muscle were extracted with acetronitrile.•C18 SPE cartridge was better than common sorbents for purifying fipronil.•A novel and reliable LC–MS/MS method was established to assay fipronil residue.•The CCα for fipronil in chicken egg and muscle was 0.002μgkg−1. A...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2016-03, Vol.1014, p.31-36 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Zhang, Meiyu Bian, Kui Zhou, Tong Song, Xuqin Liu, Qingying Meng, Chenying He, Limin |
| description | •Fipronil residues in chicken egg and muscle were extracted with acetronitrile.•C18 SPE cartridge was better than common sorbents for purifying fipronil.•A novel and reliable LC–MS/MS method was established to assay fipronil residue.•The CCα for fipronil in chicken egg and muscle was 0.002μgkg−1.
A simple, sensitive and reliable method was developed and applied to the residue analysis of fipronil in chicken egg and muscle by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Chicken egg and muscle samples were extracted with acetronitrile, then salting out by dehydration with anhydrous magnesium sulfate and sodium chloride. The extracts were purified by the C18 solid phase extraction cartridge prior to analysis by LC–MS/MS. The matrix-matched calibration curve showed a good linear within the concentration range from 0.01 to 2.00μgkg−1 (r2≥0.999). The average recoveries of fipronil at three spiked levels of 0.01, 0.1 and 1.0μgkg−1 ranged from 79.7% to 98.0%, and the relative standard deviations were less than 8.8%. The decision limit (CCα) and detection capability (CCβ) of fipronil in chicken egg and muscle matrices were all 0.002μgkg−1 and 0.01μgkg−1, respectively. The method has also been successfully applied to monitoring fipronil in the real samples. |
| doi_str_mv | 10.1016/j.jchromb.2016.01.041 |
| format | Article |
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A simple, sensitive and reliable method was developed and applied to the residue analysis of fipronil in chicken egg and muscle by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Chicken egg and muscle samples were extracted with acetronitrile, then salting out by dehydration with anhydrous magnesium sulfate and sodium chloride. The extracts were purified by the C18 solid phase extraction cartridge prior to analysis by LC–MS/MS. The matrix-matched calibration curve showed a good linear within the concentration range from 0.01 to 2.00μgkg−1 (r2≥0.999). The average recoveries of fipronil at three spiked levels of 0.01, 0.1 and 1.0μgkg−1 ranged from 79.7% to 98.0%, and the relative standard deviations were less than 8.8%. The decision limit (CCα) and detection capability (CCβ) of fipronil in chicken egg and muscle matrices were all 0.002μgkg−1 and 0.01μgkg−1, respectively. The method has also been successfully applied to monitoring fipronil in the real samples.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2016.01.041</identifier><identifier>PMID: 26871280</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Calibration ; Cartridges ; Chicken ; Chickens ; Chickens - metabolism ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Egg ; Eggs - analysis ; Fipronil ; Insecticides - analysis ; Limit of Detection ; Liquid chromatography–tandem mass spectrometry ; Liquids ; Monitoring ; Muscles ; Muscles - chemistry ; Pyrazoles - analysis ; Residue ; Solid Phase Extraction - methods ; Standard deviation ; Tandem Mass Spectrometry - methods</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-03, Vol.1014, p.31-36</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-97f2d26cf78a1d76525124060291f2233bbf5cd42c6fdc139bf9738f44ef46703</citedby><cites>FETCH-LOGICAL-c464t-97f2d26cf78a1d76525124060291f2233bbf5cd42c6fdc139bf9738f44ef46703</cites><orcidid>0000-0002-8575-9926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1570023216300484$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26871280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Meiyu</creatorcontrib><creatorcontrib>Bian, Kui</creatorcontrib><creatorcontrib>Zhou, Tong</creatorcontrib><creatorcontrib>Song, Xuqin</creatorcontrib><creatorcontrib>Liu, Qingying</creatorcontrib><creatorcontrib>Meng, Chenying</creatorcontrib><creatorcontrib>He, Limin</creatorcontrib><title>Determination of residual fipronil in chicken egg and muscle by LC–MS/MS</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>•Fipronil residues in chicken egg and muscle were extracted with acetronitrile.•C18 SPE cartridge was better than common sorbents for purifying fipronil.•A novel and reliable LC–MS/MS method was established to assay fipronil residue.•The CCα for fipronil in chicken egg and muscle was 0.002μgkg−1.
A simple, sensitive and reliable method was developed and applied to the residue analysis of fipronil in chicken egg and muscle by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Chicken egg and muscle samples were extracted with acetronitrile, then salting out by dehydration with anhydrous magnesium sulfate and sodium chloride. The extracts were purified by the C18 solid phase extraction cartridge prior to analysis by LC–MS/MS. The matrix-matched calibration curve showed a good linear within the concentration range from 0.01 to 2.00μgkg−1 (r2≥0.999). The average recoveries of fipronil at three spiked levels of 0.01, 0.1 and 1.0μgkg−1 ranged from 79.7% to 98.0%, and the relative standard deviations were less than 8.8%. The decision limit (CCα) and detection capability (CCβ) of fipronil in chicken egg and muscle matrices were all 0.002μgkg−1 and 0.01μgkg−1, respectively. The method has also been successfully applied to monitoring fipronil in the real samples.</description><subject>Animals</subject><subject>Calibration</subject><subject>Cartridges</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Chickens - metabolism</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Egg</subject><subject>Eggs - analysis</subject><subject>Fipronil</subject><subject>Insecticides - analysis</subject><subject>Limit of Detection</subject><subject>Liquid chromatography–tandem mass spectrometry</subject><subject>Liquids</subject><subject>Monitoring</subject><subject>Muscles</subject><subject>Muscles - chemistry</subject><subject>Pyrazoles - analysis</subject><subject>Residue</subject><subject>Solid Phase Extraction - methods</subject><subject>Standard deviation</subject><subject>Tandem Mass Spectrometry - methods</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtO5DAQhi0E4n0EkJdsElx2YicrhHqGYUaNWAASOyuxy-AmD7ATJHbcYW7ISQjqhi2sqkr6_qrSR8gBsBQYyONFujD3oW_rlE9jyiBlGayRbSiUSISSt-tTnyuWMC74FtmJccEYKKbEJtnislDAC7ZN_v3CAUPru2rwfUd7RwNGb8eqoc4_hr7zDfUdNffePGBH8e6OVp2l7RhNg7R-ofPZ2-v_i6vji6s9suGqJuL-qu6Sm7Pf17PzZH755-_sdJ6YTGZDUirHLZfGqaICq2TOc-AZk4yX4DgXoq5dbmzGjXTWgChrVypRuCxDl0nFxC45Wu6d3nsaMQ669dFg01Qd9mPUULACoBQ_QZUsJS9AiAnNl6gJfYwBnX4Mvq3CiwamP4zrhV4Z1x_GNQM9GZ9yh6sTY92i_Up9Kp6AkyWAk5Nnj0FH47EzaH1AM2jb-29OvAOFlJM_</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Zhang, Meiyu</creator><creator>Bian, Kui</creator><creator>Zhou, Tong</creator><creator>Song, Xuqin</creator><creator>Liu, Qingying</creator><creator>Meng, Chenying</creator><creator>He, Limin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><orcidid>https://orcid.org/0000-0002-8575-9926</orcidid></search><sort><creationdate>20160301</creationdate><title>Determination of residual fipronil in chicken egg and muscle by LC–MS/MS</title><author>Zhang, Meiyu ; Bian, Kui ; Zhou, Tong ; Song, Xuqin ; Liu, Qingying ; Meng, Chenying ; He, Limin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-97f2d26cf78a1d76525124060291f2233bbf5cd42c6fdc139bf9738f44ef46703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Calibration</topic><topic>Cartridges</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Chickens - metabolism</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Egg</topic><topic>Eggs - analysis</topic><topic>Fipronil</topic><topic>Insecticides - analysis</topic><topic>Limit of Detection</topic><topic>Liquid chromatography–tandem mass spectrometry</topic><topic>Liquids</topic><topic>Monitoring</topic><topic>Muscles</topic><topic>Muscles - chemistry</topic><topic>Pyrazoles - analysis</topic><topic>Residue</topic><topic>Solid Phase Extraction - methods</topic><topic>Standard deviation</topic><topic>Tandem Mass Spectrometry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Meiyu</creatorcontrib><creatorcontrib>Bian, Kui</creatorcontrib><creatorcontrib>Zhou, Tong</creatorcontrib><creatorcontrib>Song, Xuqin</creatorcontrib><creatorcontrib>Liu, Qingying</creatorcontrib><creatorcontrib>Meng, Chenying</creatorcontrib><creatorcontrib>He, Limin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>1014</volume><spage>31</spage><epage>36</epage><pages>31-36</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>•Fipronil residues in chicken egg and muscle were extracted with acetronitrile.•C18 SPE cartridge was better than common sorbents for purifying fipronil.•A novel and reliable LC–MS/MS method was established to assay fipronil residue.•The CCα for fipronil in chicken egg and muscle was 0.002μgkg−1.
A simple, sensitive and reliable method was developed and applied to the residue analysis of fipronil in chicken egg and muscle by liquid chromatography-tandem mass spectrometry (LC–MS/MS). Chicken egg and muscle samples were extracted with acetronitrile, then salting out by dehydration with anhydrous magnesium sulfate and sodium chloride. The extracts were purified by the C18 solid phase extraction cartridge prior to analysis by LC–MS/MS. The matrix-matched calibration curve showed a good linear within the concentration range from 0.01 to 2.00μgkg−1 (r2≥0.999). The average recoveries of fipronil at three spiked levels of 0.01, 0.1 and 1.0μgkg−1 ranged from 79.7% to 98.0%, and the relative standard deviations were less than 8.8%. The decision limit (CCα) and detection capability (CCβ) of fipronil in chicken egg and muscle matrices were all 0.002μgkg−1 and 0.01μgkg−1, respectively. The method has also been successfully applied to monitoring fipronil in the real samples.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26871280</pmid><doi>10.1016/j.jchromb.2016.01.041</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8575-9926</orcidid></addata></record> |
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| subjects | Animals Calibration Cartridges Chicken Chickens Chickens - metabolism Chromatography Chromatography, High Pressure Liquid - methods Egg Eggs - analysis Fipronil Insecticides - analysis Limit of Detection Liquid chromatography–tandem mass spectrometry Liquids Monitoring Muscles Muscles - chemistry Pyrazoles - analysis Residue Solid Phase Extraction - methods Standard deviation Tandem Mass Spectrometry - methods |
| title | Determination of residual fipronil in chicken egg and muscle by LC–MS/MS |
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