Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

Threonine is the only amino acid critically required for the pluripotency of mouse embryonic stem cells (mESCs), but the detailed mechanism remains unclear. We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in pluripotent stem cells, resulting in regulation of histone met...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-01, Vol.339 (6116), p.222-226
Hauptverfasser:	Shyh-Chang, Ng, Locasale, Jason W., Lyssiotis, Costas A., Zheng, Yuxiang, Teo, Ren Yi, Ratanasirintrawoot, Sutheera, Zhang, Jin, Onder, Tamer, Unternaehrer, Juli J., Zhu, Hao, Asara, John M., Daley, George Q., Cantley, Lewis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A - metabolism Alcohol Oxidoreductases - metabolism Amino acid metabolism Amino acids Animals Cell Differentiation Cells, Cultured Cellular biology Cellular metabolism Cellular Reprogramming chromatin Culture Media embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Enzymes Epigenesis, Genetic epigenetics Fibroblasts - cytology Fibroblasts - metabolism Genetics Glycine - metabolism Histones Histones - metabolism Individualized Instruction induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mass spectrometry Metabolic Networks and Pathways Metabolism Metabolites Methylation Mice Physiological regulation Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Protein metabolism Proteins S-adenosylmethionine S-Adenosylmethionine - metabolism Stem cells threonine Threonine - metabolism Transcription Factors - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!