Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology
Selective laser melting (SLM) technology is useful for the fabrication of porous titanium implants with complex shapes and structures. The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically an...
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Veröffentlicht in: | Dental Materials Journal 2016/01/29, Vol.35(1), pp.118-125 |
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creator | TSUKANAKA, Masako FUJIBAYASHI, Shunsuke TAKEMOTO, Mitsuru MATSUSHITA, Tomiharu KOKUBO, Tadashi NAKAMURA, Takashi SASAKI, Kiyoyuki MATSUDA, Shuichi |
description | Selective laser melting (SLM) technology is useful for the fabrication of porous titanium implants with complex shapes and structures. The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically and biochemically the specific effects of this very rough surface and the additional effects of a bioactive treatment on osteoblast proliferation and differentiation. Flat-rolled titanium materials (Ra=1.02 µm) were used as the controls. On the treated materials fabricated by SLM, we observed enhanced osteoblast differentiation compared with the flat-rolled materials and the untreated materials fabricated by SLM. No significant differences were observed between the flat-rolled materials and the untreated materials fabricated by SLM in their effects on osteoblast differentiation. We concluded that the very rough surface fabricated by SLM had to undergo a bioactive treatment to obtain a positive effect on osteoblast differentiation. |
doi_str_mv | 10.4012/dmj.2015-127 |
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The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically and biochemically the specific effects of this very rough surface and the additional effects of a bioactive treatment on osteoblast proliferation and differentiation. Flat-rolled titanium materials (Ra=1.02 µm) were used as the controls. On the treated materials fabricated by SLM, we observed enhanced osteoblast differentiation compared with the flat-rolled materials and the untreated materials fabricated by SLM. No significant differences were observed between the flat-rolled materials and the untreated materials fabricated by SLM in their effects on osteoblast differentiation. We concluded that the very rough surface fabricated by SLM had to undergo a bioactive treatment to obtain a positive effect on osteoblast differentiation.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2015-127</identifier><identifier>PMID: 26830832</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Animals ; Bioactive treatment ; Biochemistry ; Biocompatibility ; Biomedical materials ; Cell Adhesion ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Culture Media - chemistry ; Dental materials ; Dentistry ; Differentiation ; Laser beam melting ; Lasers ; Materials selection ; Materials Testing ; Mice ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Osteoblast differentiation ; Osteoblasts - physiology ; Real-Time Polymerase Chain Reaction ; Selective laser melting technology ; Surface Properties ; Tetrazolium Salts ; Titanium - chemistry ; Titanium base alloys ; Wettability</subject><ispartof>Dental Materials Journal, 2016/01/29, Vol.35(1), pp.118-125</ispartof><rights>2016 The Japanese Society for Dental Materials and Devices</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c709t-fd7d2ee36b77f269c73eea8d94febc24930780f5be407b9b1fdb68fdfbbd4df3</citedby><cites>FETCH-LOGICAL-c709t-fd7d2ee36b77f269c73eea8d94febc24930780f5be407b9b1fdb68fdfbbd4df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26830832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSUKANAKA, Masako</creatorcontrib><creatorcontrib>FUJIBAYASHI, Shunsuke</creatorcontrib><creatorcontrib>TAKEMOTO, Mitsuru</creatorcontrib><creatorcontrib>MATSUSHITA, Tomiharu</creatorcontrib><creatorcontrib>KOKUBO, Tadashi</creatorcontrib><creatorcontrib>NAKAMURA, Takashi</creatorcontrib><creatorcontrib>SASAKI, Kiyoyuki</creatorcontrib><creatorcontrib>MATSUDA, Shuichi</creatorcontrib><creatorcontrib>Department of Orthopaedic Surgery</creatorcontrib><creatorcontrib>Sagawa Printing</creatorcontrib><creatorcontrib>College of Life and Health Sciences</creatorcontrib><creatorcontrib>Kyoto University</creatorcontrib><creatorcontrib>Department of Biomedical Sciences</creatorcontrib><creatorcontrib>National Hospital Organization Kyoto Medical Center</creatorcontrib><creatorcontrib>Graduate School of Medicine</creatorcontrib><creatorcontrib>Chubu University</creatorcontrib><title>Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>Selective laser melting (SLM) technology is useful for the fabrication of porous titanium implants with complex shapes and structures. The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically and biochemically the specific effects of this very rough surface and the additional effects of a bioactive treatment on osteoblast proliferation and differentiation. Flat-rolled titanium materials (Ra=1.02 µm) were used as the controls. On the treated materials fabricated by SLM, we observed enhanced osteoblast differentiation compared with the flat-rolled materials and the untreated materials fabricated by SLM. No significant differences were observed between the flat-rolled materials and the untreated materials fabricated by SLM in their effects on osteoblast differentiation. We concluded that the very rough surface fabricated by SLM had to undergo a bioactive treatment to obtain a positive effect on osteoblast differentiation.</description><subject>Animals</subject><subject>Bioactive treatment</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Culture Media - chemistry</subject><subject>Dental materials</subject><subject>Dentistry</subject><subject>Differentiation</subject><subject>Laser beam melting</subject><subject>Lasers</subject><subject>Materials selection</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Microscopy, Confocal</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osteoblast differentiation</subject><subject>Osteoblasts - physiology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Selective laser melting technology</subject><subject>Surface Properties</subject><subject>Tetrazolium Salts</subject><subject>Titanium - chemistry</subject><subject>Titanium base alloys</subject><subject>Wettability</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1vFCEYhydGY7fVm2fD0YNT-ZqBOdrGVpMmXnonMLxs2TBQgTXZS_92WafdqyYEQt6Hhxd-XfeB4EuOCf1il90lxWToCRWvug2RkvSEjeR1t8FUip4PXJx156XsMObTKOXb7oyOkmHJ6KZ7uvJJz9X_BlQz6LpArOgxpyVVKCiVCskEXSqy3jnIrep19SmiNqqvOvr9ghZdIXsdCnLaZD-3rUXmgAoEWN1NARktEKqPW1RhfogppO3hXffGtXPw_nm96O5vvt1ff-_vft7-uP56188CT7V3VlgKwEYjhKPjNAsGoKWduAMzUz4xLCR2gwGOhZkMcdaM0llnjOXWsYvu06ptL_u1h1LV4ssMIegIaV8UkVgSLCgn_4MOfBoEo_9GxUgZp5KLhn5e0TmnUjI49Zj9ovNBEayOMaoWozrGqFqMDf_4bN6bBewJfsmtAbcr0Krtv0OKwUdQu7TPsf2jsgdsIa7KUWHMBkzU0Y4JkW2iAx3bgwVupqvVtCtVb-F0lc7VzwH-9sVaV8fppb9TcX7QWUFkfwBp8spf</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>TSUKANAKA, Masako</creator><creator>FUJIBAYASHI, Shunsuke</creator><creator>TAKEMOTO, Mitsuru</creator><creator>MATSUSHITA, Tomiharu</creator><creator>KOKUBO, Tadashi</creator><creator>NAKAMURA, Takashi</creator><creator>SASAKI, Kiyoyuki</creator><creator>MATSUDA, Shuichi</creator><general>The Japanese Society for Dental Materials and Devices</general><general>Japanese Society for Dental Materials and Devices</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>2016</creationdate><title>Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology</title><author>TSUKANAKA, Masako ; FUJIBAYASHI, Shunsuke ; TAKEMOTO, Mitsuru ; MATSUSHITA, Tomiharu ; KOKUBO, Tadashi ; NAKAMURA, Takashi ; SASAKI, Kiyoyuki ; MATSUDA, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c709t-fd7d2ee36b77f269c73eea8d94febc24930780f5be407b9b1fdb68fdfbbd4df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bioactive treatment</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Cell Adhesion</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Culture Media - chemistry</topic><topic>Dental materials</topic><topic>Dentistry</topic><topic>Differentiation</topic><topic>Laser beam melting</topic><topic>Lasers</topic><topic>Materials selection</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Microscopy, Confocal</topic><topic>Microscopy, Electron, Scanning</topic><topic>Osteoblast differentiation</topic><topic>Osteoblasts - physiology</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Selective laser melting technology</topic><topic>Surface Properties</topic><topic>Tetrazolium Salts</topic><topic>Titanium - chemistry</topic><topic>Titanium base alloys</topic><topic>Wettability</topic><toplevel>online_resources</toplevel><creatorcontrib>TSUKANAKA, Masako</creatorcontrib><creatorcontrib>FUJIBAYASHI, Shunsuke</creatorcontrib><creatorcontrib>TAKEMOTO, Mitsuru</creatorcontrib><creatorcontrib>MATSUSHITA, Tomiharu</creatorcontrib><creatorcontrib>KOKUBO, Tadashi</creatorcontrib><creatorcontrib>NAKAMURA, Takashi</creatorcontrib><creatorcontrib>SASAKI, Kiyoyuki</creatorcontrib><creatorcontrib>MATSUDA, Shuichi</creatorcontrib><creatorcontrib>Department of Orthopaedic Surgery</creatorcontrib><creatorcontrib>Sagawa Printing</creatorcontrib><creatorcontrib>College of Life and Health Sciences</creatorcontrib><creatorcontrib>Kyoto University</creatorcontrib><creatorcontrib>Department of Biomedical Sciences</creatorcontrib><creatorcontrib>National Hospital Organization Kyoto Medical Center</creatorcontrib><creatorcontrib>Graduate School of Medicine</creatorcontrib><creatorcontrib>Chubu University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSUKANAKA, Masako</au><au>FUJIBAYASHI, Shunsuke</au><au>TAKEMOTO, Mitsuru</au><au>MATSUSHITA, Tomiharu</au><au>KOKUBO, Tadashi</au><au>NAKAMURA, Takashi</au><au>SASAKI, Kiyoyuki</au><au>MATSUDA, Shuichi</au><aucorp>Department of Orthopaedic Surgery</aucorp><aucorp>Sagawa Printing</aucorp><aucorp>College of Life and Health Sciences</aucorp><aucorp>Kyoto University</aucorp><aucorp>Department of Biomedical Sciences</aucorp><aucorp>National Hospital Organization Kyoto Medical Center</aucorp><aucorp>Graduate School of Medicine</aucorp><aucorp>Chubu University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2016</date><risdate>2016</risdate><volume>35</volume><issue>1</issue><spage>118</spage><epage>125</epage><pages>118-125</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>Selective laser melting (SLM) technology is useful for the fabrication of porous titanium implants with complex shapes and structures. The materials fabricated by SLM characteristically have a very rough surface (average surface roughness, Ra=24.58 µm). In this study, we evaluated morphologically and biochemically the specific effects of this very rough surface and the additional effects of a bioactive treatment on osteoblast proliferation and differentiation. Flat-rolled titanium materials (Ra=1.02 µm) were used as the controls. On the treated materials fabricated by SLM, we observed enhanced osteoblast differentiation compared with the flat-rolled materials and the untreated materials fabricated by SLM. No significant differences were observed between the flat-rolled materials and the untreated materials fabricated by SLM in their effects on osteoblast differentiation. We concluded that the very rough surface fabricated by SLM had to undergo a bioactive treatment to obtain a positive effect on osteoblast differentiation.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>26830832</pmid><doi>10.4012/dmj.2015-127</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Bioactive treatment Biochemistry Biocompatibility Biomedical materials Cell Adhesion Cell Differentiation Cell Proliferation Cells, Cultured Culture Media - chemistry Dental materials Dentistry Differentiation Laser beam melting Lasers Materials selection Materials Testing Mice Microscopy, Confocal Microscopy, Electron, Scanning Osteoblast differentiation Osteoblasts - physiology Real-Time Polymerase Chain Reaction Selective laser melting technology Surface Properties Tetrazolium Salts Titanium - chemistry Titanium base alloys Wettability |
title | Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology |
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