Chemical Composition, Cytotoxic and Antibacterial Activities of the Essential Oil from the Tunisian Ononis angustissima L. (Fabaceae)
The chemical composition, cytotoxic and antibacterial activities of the hydrodistilled essential oil of the aerial parts of Ononis angustissima from south Tunisia has been evaluated. The oil yield was 0.04% (w/w). The chemical composition, determined by GC and GC-MS is reported for the first time. F...
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| Veröffentlicht in: | Journal of Oleo Science 2016, Vol.65(4), pp.339-345 |
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| creator | Ghribi, Lotfi Nejma, Aymen Ben Besbes, Malek Harzalla-Skhiri, Fethia Flamini, Guido Jannet, Hichem Ben |
| description | The chemical composition, cytotoxic and antibacterial activities of the hydrodistilled essential oil of the aerial parts of Ononis angustissima from south Tunisia has been evaluated. The oil yield was 0.04% (w/w). The chemical composition, determined by GC and GC-MS is reported for the first time. Forty-five components, accounting for 93.7% of the total oil have been identified. The oil was characterized by a high proportion of oxygenated sesquiterpenes (33.2%), followed by sesquiterpene hydrocarbons (6.3%) and apocarotenoids (10.3%). The main components of the oil were α-eudesmol (22.4%), 2-tridecanone (9.3%) and acetophenone (7.4%). The essential oil was tested for its possible cytotoxic activity towards the human cervical cell line HeLa using the MTT assay and the antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and the clinical strain Acinetobacter sp. This oil exerted a cytotoxic activity with an IC50 of 0.53 ± 0.02 mg/mL and a significant antibacterial effect against P. aeruginosa and E. faecalis. |
| doi_str_mv | 10.5650/jos.ess15242 |
| format | Article |
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(Fabaceae)</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Ghribi, Lotfi ; Nejma, Aymen Ben ; Besbes, Malek ; Harzalla-Skhiri, Fethia ; Flamini, Guido ; Jannet, Hichem Ben</creator><creatorcontrib>Ghribi, Lotfi ; Nejma, Aymen Ben ; Besbes, Malek ; Harzalla-Skhiri, Fethia ; Flamini, Guido ; Jannet, Hichem Ben</creatorcontrib><description>The chemical composition, cytotoxic and antibacterial activities of the hydrodistilled essential oil of the aerial parts of Ononis angustissima from south Tunisia has been evaluated. The oil yield was 0.04% (w/w). The chemical composition, determined by GC and GC-MS is reported for the first time. Forty-five components, accounting for 93.7% of the total oil have been identified. The oil was characterized by a high proportion of oxygenated sesquiterpenes (33.2%), followed by sesquiterpene hydrocarbons (6.3%) and apocarotenoids (10.3%). The main components of the oil were α-eudesmol (22.4%), 2-tridecanone (9.3%) and acetophenone (7.4%). The essential oil was tested for its possible cytotoxic activity towards the human cervical cell line HeLa using the MTT assay and the antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and the clinical strain Acinetobacter sp. This oil exerted a cytotoxic activity with an IC50 of 0.53 ± 0.02 mg/mL and a significant antibacterial effect against P. aeruginosa and E. faecalis.</description><identifier>ISSN: 1345-8957</identifier><identifier>EISSN: 1347-3352</identifier><identifier>DOI: 10.5650/jos.ess15242</identifier><identifier>PMID: 26972463</identifier><language>eng</language><publisher>Japan: Japan Oil Chemists' Society</publisher><subject>Accounting ; Acinetobacter ; antibacterial activity ; Antibacterial properties ; Biotechnology ; Carotenoids - analysis ; Cells, Cultured ; Chemical composition ; Chromatography, Gas ; composition ; cytotoxic activity ; Drug Resistance, Bacterial ; Enterococcus faecalis ; Enterococcus faecalis - drug effects ; Escherichia coli ; Escherichia coli - drug effects ; essential oil ; Fabaceae ; Fabaceae - chemistry ; Gas Chromatography-Mass Spectrometry ; Human ; Humans ; Oils, Volatile - chemistry ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Ononis ; Ononis angustissima ; Oxygenated ; Plant Oils - chemistry ; Plant Oils - isolation & purification ; Plant Oils - pharmacology ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Sesquiterpenes - analysis ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Tunisia ; α-eudesmol</subject><ispartof>Journal of Oleo Science, 2016, Vol.65(4), pp.339-345</ispartof><rights>2016 by Japan Oil Chemists' Society</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-93cf3e92dbda748b50b3f3e2d69ad81c11a61665dea77bb41848d1316ed8f5c53</citedby><cites>FETCH-LOGICAL-c632t-93cf3e92dbda748b50b3f3e2d69ad81c11a61665dea77bb41848d1316ed8f5c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26972463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghribi, Lotfi</creatorcontrib><creatorcontrib>Nejma, Aymen Ben</creatorcontrib><creatorcontrib>Besbes, Malek</creatorcontrib><creatorcontrib>Harzalla-Skhiri, Fethia</creatorcontrib><creatorcontrib>Flamini, Guido</creatorcontrib><creatorcontrib>Jannet, Hichem Ben</creatorcontrib><title>Chemical Composition, Cytotoxic and Antibacterial Activities of the Essential Oil from the Tunisian Ononis angustissima L. (Fabaceae)</title><title>Journal of Oleo Science</title><addtitle>J Oleo Sci</addtitle><description>The chemical composition, cytotoxic and antibacterial activities of the hydrodistilled essential oil of the aerial parts of Ononis angustissima from south Tunisia has been evaluated. The oil yield was 0.04% (w/w). The chemical composition, determined by GC and GC-MS is reported for the first time. Forty-five components, accounting for 93.7% of the total oil have been identified. The oil was characterized by a high proportion of oxygenated sesquiterpenes (33.2%), followed by sesquiterpene hydrocarbons (6.3%) and apocarotenoids (10.3%). The main components of the oil were α-eudesmol (22.4%), 2-tridecanone (9.3%) and acetophenone (7.4%). The essential oil was tested for its possible cytotoxic activity towards the human cervical cell line HeLa using the MTT assay and the antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and the clinical strain Acinetobacter sp. This oil exerted a cytotoxic activity with an IC50 of 0.53 ± 0.02 mg/mL and a significant antibacterial effect against P. aeruginosa and E. faecalis.</description><subject>Accounting</subject><subject>Acinetobacter</subject><subject>antibacterial activity</subject><subject>Antibacterial properties</subject><subject>Biotechnology</subject><subject>Carotenoids - analysis</subject><subject>Cells, Cultured</subject><subject>Chemical composition</subject><subject>Chromatography, Gas</subject><subject>composition</subject><subject>cytotoxic activity</subject><subject>Drug Resistance, Bacterial</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>essential oil</subject><subject>Fabaceae</subject><subject>Fabaceae - chemistry</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Human</subject><subject>Humans</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - isolation & purification</subject><subject>Oils, Volatile - pharmacology</subject><subject>Ononis</subject><subject>Ononis angustissima</subject><subject>Oxygenated</subject><subject>Plant Oils - chemistry</subject><subject>Plant Oils - isolation & purification</subject><subject>Plant Oils - pharmacology</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Sesquiterpenes - analysis</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Tunisia</subject><subject>α-eudesmol</subject><issn>1345-8957</issn><issn>1347-3352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9v0zAUB_AIgdgY3DgjS1yGtJTYjn_kWKKNIVXqZZwjx3lZXSVx8XMQ-wP4v3HbtQcuu9jWex9_Jftl2UdaLIQUxdetxwUgUsFK9iq7pLxUOeeCvT6cRa4roS6yd4jbokh1od5mF0xWipWSX2Z_6w2MzpqB1H7ceXTR-emG1E_RR__HWWKmjiyn6FpjIwSX4NJG9zs5QOJ7EjdAbhEhkdRbu4H0wY-H8sM8OXRmIuvJp1OKepwxOkQ3GrJakOs7k1LBwJf32ZveDAgfnver7Ofd7UN9n6_W33_Uy1VuJWcxr7jtOVSsazujSt2KouWpwDpZmU5TS6mRVErRgVGqbUuqS91RTiV0uhdW8Kvs-pi7C_7XDBib0aGFYTAT-BkbqgtNi5IX9GWqtGBclnRPP_9Ht34OU3pIUkqr9NWUJXVzVDZ4xAB9swvpI8JTQ4tmP8l0C5vTJBP_9Bw6tyN0Z3waXQLfjmCL0TzCGZgQnR3gkCZFU-6XU-q5aTcmNDDxf7E4su4</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Ghribi, Lotfi</creator><creator>Nejma, Aymen Ben</creator><creator>Besbes, Malek</creator><creator>Harzalla-Skhiri, Fethia</creator><creator>Flamini, Guido</creator><creator>Jannet, Hichem Ben</creator><general>Japan Oil Chemists' Society</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>2016</creationdate><title>Chemical Composition, Cytotoxic and Antibacterial Activities of the Essential Oil from the Tunisian Ononis angustissima L. 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The essential oil was tested for its possible cytotoxic activity towards the human cervical cell line HeLa using the MTT assay and the antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and the clinical strain Acinetobacter sp. This oil exerted a cytotoxic activity with an IC50 of 0.53 ± 0.02 mg/mL and a significant antibacterial effect against P. aeruginosa and E. faecalis.</abstract><cop>Japan</cop><pub>Japan Oil Chemists' Society</pub><pmid>26972463</pmid><doi>10.5650/jos.ess15242</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Accounting Acinetobacter antibacterial activity Antibacterial properties Biotechnology Carotenoids - analysis Cells, Cultured Chemical composition Chromatography, Gas composition cytotoxic activity Drug Resistance, Bacterial Enterococcus faecalis Enterococcus faecalis - drug effects Escherichia coli Escherichia coli - drug effects essential oil Fabaceae Fabaceae - chemistry Gas Chromatography-Mass Spectrometry Human Humans Oils, Volatile - chemistry Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Ononis Ononis angustissima Oxygenated Plant Oils - chemistry Plant Oils - isolation & purification Plant Oils - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Sesquiterpenes - analysis Staphylococcus aureus Staphylococcus aureus - drug effects Tunisia α-eudesmol |
| title | Chemical Composition, Cytotoxic and Antibacterial Activities of the Essential Oil from the Tunisian Ononis angustissima L. (Fabaceae) |
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