Quantitative Detection of PEGylated Biomacromolecules in Biological Fluids by NMR

The accumulation, biodistribution, and clearance profiles of therapeutic agents are key factors relevant to their efficacy. Determining these properties constitutes an ongoing experimental challenge. Many such therapeutics, including small molecules, peptides, proteins, tissue scaffolds, and drug de...

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Veröffentlicht in:	Analytical chemistry (Washington) 2016-04, Vol.88 (7), p.3730-3738
Hauptverfasser:	Alvares, Rohan D. A, Hasabnis, Advait, Prosser, R. Scott, Macdonald, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Blood Body fluids Carbon Radioisotopes Cattle Clearances Computational fluid dynamics Filtering Fluid flow Fluids Goats Male Molecules NMR Nuclear magnetic resonance Peptides Polyethylene Glycols - analysis Proteins Proton Magnetic Resonance Spectroscopy Protons Rats Rats, Sprague-Dawley Serum Albumin, Bovine - analysis Swine
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