Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats

Sulpiride and ethylene glycol monomethyl ether (EGME) are known ovarian toxicants that stimulate prolactin (PRL) secretion, resulting in hypertrophy of the corpora lutea and increased progesterone (P4) production. The purpose of the present study was to investigate how the PRL stimulatory agents aff...

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Veröffentlicht in:	Journal of applied toxicology 2016-06, Vol.36 (6), p.769-776
Hauptverfasser:	Taketa, Yoshikazu, Inoue, Kaoru, Takahashi, Miwa, Sakamoto, Yohei, Watanabe, Gen, Taya, Kazuyoshi, Yoshida, Midori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - chemically induced Adenocarcinoma - pathology Adenocarcinoma - prevention & control Age Animals Anticarcinogenic Agents - adverse effects Anticarcinogenic Agents - therapeutic use Antifreeze solutions Carcinogenesis - chemically induced Carcinogenesis - drug effects Carcinogenicity Carcinogens Carcinogens - chemistry Carcinogens - toxicity Donryu rats endometrial adenocarcinoma Endometrial cancer Endometrial Hyperplasia - blood Endometrial Hyperplasia - chemically induced Endometrial Hyperplasia - pathology Endometrial Hyperplasia - prevention & control Endometrial Neoplasms - blood Endometrial Neoplasms - chemically induced Endometrial Neoplasms - pathology Endometrial Neoplasms - prevention & control Endometrium - drug effects Endometrium - pathology Estrus - drug effects Ethers Ethylene glycol ethylene glycol monomethyl ether Ethylene Glycols - adverse effects Ethylene Glycols - therapeutic use Female Infertility, Female - blood Infertility, Female - chemically induced Infertility, Female - pathology Infertility, Female - prevention & control Methylnitronitrosoguanidine - analogs & derivatives Methylnitronitrosoguanidine - chemistry Methylnitronitrosoguanidine - toxicity Organ Size - drug effects Ovary - drug effects Ovary - pathology Precancerous Conditions - blood Precancerous Conditions - chemically induced Precancerous Conditions - pathology Precancerous Conditions - prevention & control Progesterone - agonists Progesterone - blood Progesterone - secretion prolactin Prolactin - agonists Prolactin - blood Prolactin - secretion Rats Rats, Inbred Strains Secretions Serums sulpiride Sulpiride - adverse effects Sulpiride - therapeutic use Toxicology Uterus - drug effects Uterus - pathology Weight Gain - drug effects
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