α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration

Lysosomal storage disorders (LSD) are caused by lysosomal dysfunction usually as a consequence of deficiency of a single enzyme required for the metabolism of macromolecules, such as lipids, glycoproteins, and mucopolysaccharides. For instance, the lack of α‐galactosidase A (GLA) activity in Fabry d...

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Veröffentlicht in:	Advanced healthcare materials 2016-04, Vol.5 (7), p.829-840
Hauptverfasser:	Cabrera, Ingrid, Abasolo, Ibane, Corchero, José L., Elizondo, Elisa, Gil, Pilar Rivera, Moreno, Evelyn, Faraudo, Jordi, Sala, Santi, Bueno, Dolores, González-Mira, Elisabet, Rivas, Merche, Melgarejo, Marta, Pulido, Daniel, Albericio, Fernando, Royo, Miriam, Villaverde, Antonio, García-Parajo, Maria F., Schwartz Jr, Simó, Ventosa, Nora, Veciana, Jaume
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Galactosidase - metabolism Animals Aorta - pathology Cellular compressed CO2 Effectiveness Endocytosis Endothelial Cells - metabolism Enzymes Fabry disease Flow Cytometry Humans Intracellular Space - metabolism Liposomes - chemistry Mathematical models Mice, Knockout Models, Molecular Nanoconjugates - chemistry Nanoconjugates - ultrastructure nanoliposomes Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure Penetration Peptides Reduction RGD targeting α-galactosidase A
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