Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice
Highlights • Hypercholesterolemic mice have reduced insulin secretion. • We hypothesized that pravastatin treatment improves insulin secretion. • Pravastatin chronic treatment impaired glucose stimulated insulin secretion. • Pravastatin also decreased the expression of exocytotic SNARE proteins. • P...
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| Veröffentlicht in: | Toxicology (Amsterdam) 2016-02, Vol.344, p.42-52 |
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| container_title | Toxicology (Amsterdam) |
| container_volume | 344 |
| creator | Lorza-Gil, Estela Salerno, Alessandro G Wanschel, Amarylis C.B.A Vettorazzi, Jean F Ferreira, Mônica S Rentz, Thiago Catharino, Rodrigo R Oliveira, Helena C.F |
| description | Highlights • Hypercholesterolemic mice have reduced insulin secretion. • We hypothesized that pravastatin treatment improves insulin secretion. • Pravastatin chronic treatment impaired glucose stimulated insulin secretion. • Pravastatin also decreased the expression of exocytotic SNARE proteins. • Pravastatin induced apoptosis signaling and death rates in pancreatic islets. |
| doi_str_mv | 10.1016/j.tox.2015.12.007 |
| format | Article |
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Salerno, Alessandro G ; Wanschel, Amarylis C.B.A ; Vettorazzi, Jean F ; Ferreira, Mônica S ; Rentz, Thiago ; Catharino, Rodrigo R ; Oliveira, Helena C.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-bef2915995bd1e833f84429f3d8f39a57ed4e48064261560ba04b5a1f88845553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Drug Administration Schedule</topic><topic>Emergency</topic><topic>Exocytosis - drug effects</topic><topic>Exocytosis - physiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity</topic><topic>Hypercholesterolemia - genetics</topic><topic>Hypercholesterolemia - metabolism</topic><topic>Hypercholesterolemia - pathology</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Insulin secretion</topic><topic>Insulin-Secreting Cells - drug effects</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Insulin-Secreting Cells - pathology</topic><topic>LDL receptor</topic><topic>Markers</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Pravastatin - toxicity</topic><topic>Proteins</topic><topic>Receptors, LDL - deficiency</topic><topic>Receptors, LDL - genetics</topic><topic>Secretions</topic><topic>SNARE proteins</topic><topic>Statins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorza-Gil, Estela</creatorcontrib><creatorcontrib>Salerno, Alessandro G</creatorcontrib><creatorcontrib>Wanschel, Amarylis C.B.A</creatorcontrib><creatorcontrib>Vettorazzi, Jean F</creatorcontrib><creatorcontrib>Ferreira, Mônica S</creatorcontrib><creatorcontrib>Rentz, Thiago</creatorcontrib><creatorcontrib>Catharino, Rodrigo R</creatorcontrib><creatorcontrib>Oliveira, Helena C.F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorza-Gil, Estela</au><au>Salerno, Alessandro G</au><au>Wanschel, Amarylis C.B.A</au><au>Vettorazzi, Jean F</au><au>Ferreira, Mônica S</au><au>Rentz, Thiago</au><au>Catharino, Rodrigo R</au><au>Oliveira, Helena C.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2016-02-17</date><risdate>2016</risdate><volume>344</volume><spage>42</spage><epage>52</epage><pages>42-52</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><abstract>Highlights • Hypercholesterolemic mice have reduced insulin secretion. • We hypothesized that pravastatin treatment improves insulin secretion. • Pravastatin chronic treatment impaired glucose stimulated insulin secretion. • Pravastatin also decreased the expression of exocytotic SNARE proteins. • Pravastatin induced apoptosis signaling and death rates in pancreatic islets.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26875785</pmid><doi>10.1016/j.tox.2015.12.007</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Apoptosis Cholesterol Diabetes Drug Administration Schedule Emergency Exocytosis - drug effects Exocytosis - physiology Female Glucose Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity Hypercholesterolemia - genetics Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Insulin Insulin - metabolism Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology LDL receptor Markers Mice Mice, Inbred C57BL Mice, Knockout Pravastatin - toxicity Proteins Receptors, LDL - deficiency Receptors, LDL - genetics Secretions SNARE proteins Statins |
| title | Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice |
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