Silver nanoparticles strongly enhance and restore bactericidal activity of inactive antibiotics against multiresistant Enterobacteriaceae

[Display omitted] •Silver NPs restore bactericidal effect of antibiotics against resistant bacteria.•Double disk synergy test did not prove beta-lactamase production in bacteria.•Rigidity of bacterial cell wall was affected by restored antibiotic’s activity.•Antibiotics combined with silver NPs show...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-06, Vol.142, p.392-399
Hauptverfasser:	Panáček, Aleš, Smékalová, Monika, Večeřová, Renata, Bogdanová, Kateřina, Röderová, Magdaléna, Kolář, Milan, Kilianová, Martina, Hradilová, Šárka, Froning, Jens P., Havrdová, Markéta, Prucek, Robert, Zbořil, Radek, Kvítek, Libor
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial properties Antibiotic Antibiotics Antiinfectives and antibacterials Bacteria beta-Lactamases - genetics beta-Lactamases - metabolism Cefotaxime - pharmacology Ceftazidime - pharmacology Ciprofloxacin - pharmacology Cytotoxicity Drug Resistance, Multiple, Bacterial - drug effects Drug Resistance, Multiple, Bacterial - genetics Drug Synergism Enterobacteriaceae Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - growth & development Gene Expression Gentamicins - pharmacology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - growth & development Mammals Medical Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Microbial Sensitivity Tests Multilevel Nanoparticles Resistant bacteria Silver - pharmacology Silver nanoparticle Synergism Thienamycins - pharmacology
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