Where Is PTEN?
A tumor suppressor protein may function in multiple locations inside and outside the originating cell. [Also see Reports by Bassi et al. and Hopkins et al. ] There are plenty of examples in biology of finding things in unexpected places, such as bacteria thriving in the stomach or deep in Earth'...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-07, Vol.341 (6144), p.355-356 |
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| creator | Leslie, Nicholas R. Brunton, Valerie G. |
| description | A tumor suppressor protein may function in multiple locations inside and outside the originating cell.
[Also see Reports by
Bassi
et al.
and
Hopkins
et al.
]
There are plenty of examples in biology of finding things in unexpected places, such as bacteria thriving in the stomach or deep in Earth's crust, or proteins that have acquired “moonlighting” functions when in new cellular locations. On pages 399 and 395 of this issue, two reports describe newly identified aspects of the functions of phosphatase and tensin homolog (PTEN), a tumor suppressor protein. Both studies focus on where these functions are fulfilled. Hopkins
et al.
(
1
) describe a secreted form of PTEN that can be transferred between cells, potentially for intercellular tumor suppression. Bassi
et al.
(
2
) present a new mechanism of PTEN regulation in response to DNA damage that controls PTEN localization in the nucleus. Both discoveries have implications for cancer therapy. |
| doi_str_mv | 10.1126/science.1242541 |
| format | Article |
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[Also see Reports by
Bassi
et al.
and
Hopkins
et al.
]
There are plenty of examples in biology of finding things in unexpected places, such as bacteria thriving in the stomach or deep in Earth's crust, or proteins that have acquired “moonlighting” functions when in new cellular locations. On pages 399 and 395 of this issue, two reports describe newly identified aspects of the functions of phosphatase and tensin homolog (PTEN), a tumor suppressor protein. Both studies focus on where these functions are fulfilled. Hopkins
et al.
(
1
) describe a secreted form of PTEN that can be transferred between cells, potentially for intercellular tumor suppression. Bassi
et al.
(
2
) present a new mechanism of PTEN regulation in response to DNA damage that controls PTEN localization in the nucleus. Both discoveries have implications for cancer therapy.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1242541</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington: American Association for the Advancement of Science</publisher><subject>Bacteria ; Biology ; Cancer ; Cell lines ; Cellular biology ; Control ; Cultured tumor cells ; Deoxyribonucleic acid ; DNA damage ; Localization ; Oncology ; PERSPECTIVES ; Proteins ; Secretion ; Signals ; Stem cells ; Stomach ; Stromal cells ; Tumor cell line ; Tumors</subject><ispartof>Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6144), p.355-356</ispartof><rights>Copyright © 2013 American Association for the Advancement of Science</rights><rights>Copyright © 2013, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-722bc52e1fdef348ed5eb42e4d51e39e77e085598c40ee4e0964fdc73339c46e3</citedby><cites>FETCH-LOGICAL-c390t-722bc52e1fdef348ed5eb42e4d51e39e77e085598c40ee4e0964fdc73339c46e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23491100$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23491100$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids></links><search><creatorcontrib>Leslie, Nicholas R.</creatorcontrib><creatorcontrib>Brunton, Valerie G.</creatorcontrib><title>Where Is PTEN?</title><title>Science (American Association for the Advancement of Science)</title><description>A tumor suppressor protein may function in multiple locations inside and outside the originating cell.
[Also see Reports by
Bassi
et al.
and
Hopkins
et al.
]
There are plenty of examples in biology of finding things in unexpected places, such as bacteria thriving in the stomach or deep in Earth's crust, or proteins that have acquired “moonlighting” functions when in new cellular locations. On pages 399 and 395 of this issue, two reports describe newly identified aspects of the functions of phosphatase and tensin homolog (PTEN), a tumor suppressor protein. Both studies focus on where these functions are fulfilled. Hopkins
et al.
(
1
) describe a secreted form of PTEN that can be transferred between cells, potentially for intercellular tumor suppression. Bassi
et al.
(
2
) present a new mechanism of PTEN regulation in response to DNA damage that controls PTEN localization in the nucleus. Both discoveries have implications for cancer therapy.</description><subject>Bacteria</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cell lines</subject><subject>Cellular biology</subject><subject>Control</subject><subject>Cultured tumor cells</subject><subject>Deoxyribonucleic acid</subject><subject>DNA damage</subject><subject>Localization</subject><subject>Oncology</subject><subject>PERSPECTIVES</subject><subject>Proteins</subject><subject>Secretion</subject><subject>Signals</subject><subject>Stem cells</subject><subject>Stomach</subject><subject>Stromal cells</subject><subject>Tumor cell line</subject><subject>Tumors</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpdkE1Lw0AQhhdRMFa9ehIKXrykndmPJHsSKVULRT1UPC7pZoIJaVJ3k4P_3oQED57mMM_7MvMwdoOwQOTR0tuCaksL5JIriScsQNAq1BzEKQsARBQmEKtzduF9CdDvtAjY9ecXOZpv_Px9t359uGRneVp5uprmjH08rXerl3D79rxZPW5DKzS0Ycz53ipOmGeUC5lQpmgvOclMIQlNcUyQKKUTK4FIEuhI5pmNhRDayojEjN2PvUfXfHfkW3MovKWqSmtqOm8wgQQijGLVo3f_0LLpXN1fZ1Di8KqGgVqOlHWN945yc3TFIXU_BsEMfszkx0x--sTtmCh927g_nAupEXtdvzQVX5E</recordid><startdate>20130726</startdate><enddate>20130726</enddate><creator>Leslie, Nicholas R.</creator><creator>Brunton, Valerie G.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130726</creationdate><title>Where Is PTEN?</title><author>Leslie, Nicholas R. ; 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[Also see Reports by
Bassi
et al.
and
Hopkins
et al.
]
There are plenty of examples in biology of finding things in unexpected places, such as bacteria thriving in the stomach or deep in Earth's crust, or proteins that have acquired “moonlighting” functions when in new cellular locations. On pages 399 and 395 of this issue, two reports describe newly identified aspects of the functions of phosphatase and tensin homolog (PTEN), a tumor suppressor protein. Both studies focus on where these functions are fulfilled. Hopkins
et al.
(
1
) describe a secreted form of PTEN that can be transferred between cells, potentially for intercellular tumor suppression. Bassi
et al.
(
2
) present a new mechanism of PTEN regulation in response to DNA damage that controls PTEN localization in the nucleus. Both discoveries have implications for cancer therapy.</abstract><cop>Washington</cop><pub>American Association for the Advancement of Science</pub><doi>10.1126/science.1242541</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6144), p.355-356 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808061675 |
| source | JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Bacteria Biology Cancer Cell lines Cellular biology Control Cultured tumor cells Deoxyribonucleic acid DNA damage Localization Oncology PERSPECTIVES Proteins Secretion Signals Stem cells Stomach Stromal cells Tumor cell line Tumors |
| title | Where Is PTEN? |
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