A Comparative Study of Collagen Matrix Density Effect on Endothelial Sprout Formation Using Experimental and Computational Approaches

A thorough understanding of determining factors in angiogenesis is a necessary step to control the development of new blood vessels. Extracellular matrix density is known to have a significant influence on cellular behaviors and consequently can regulate vessel formation. The utilization of experime...

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Veröffentlicht in:	Annals of biomedical engineering 2016-04, Vol.44 (4), p.929-941
Hauptverfasser:	Shamloo, Amir, Mohammadaliha, Negar, Heilshorn, Sarah C., Bauer, Amy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood vessels Cell Count Cellular Classical Mechanics Collagen Collagens Comparative studies Computation Density Electrochemical machining Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Experimental methods Extracellular Matrix Formations Humans Mathematical models Models, Biological Neovascularization, Physiologic - drug effects Pore size Vascular Endothelial Growth Factor A - pharmacology
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