Cocaine Disinhibits Dopamine Neurons by Potentiation of GABA Transmission in the Ventral Tegmental Area

Drug-evoked synaptic plasticity in the mesolimbic system reshapes circuit function and drives drug-adaptive behavior. Much research has focused on excitatory transmission in the ventral tegmental area (VTA) and the nucleus accumbens (NAc). How drug-evoked synaptic plasticity of inhibitory transmissi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-09, Vol.341 (6153), p.1521-1525
Hauptverfasser:	Bocklisch, Christina, Pascoli, Vincent, Wong, Jovi C. Y., House, David R. C., Yvon, Cédric, de Roo, Mathias, Tan, Kelly R., Lüscher, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral neuroscience Biological and medical sciences Brain Circuits Cocaine Cocaine - pharmacology Cocaine-Related Disorders - physiopathology Dopamine Dopaminergic Neurons - metabolism Drug therapy Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - drug effects gamma-Aminobutyric Acid - metabolism In vitro methods and tests In vivo methods and tests Injections Mathematical functions Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Narcotics Neuronal Plasticity - drug effects Neurons Neuropharmacology Neuroscience Pharmacology. Drug treatments Plasticity Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sensitization Synapses Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology Ventral tegmental area Ventral Tegmental Area - metabolism Vertebrates: nervous system and sense organs
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