Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles

Nanoparticles delivering immunosuppressive drug molecules to the human peripheral blood mononuclear cells. [Display omitted] •We prepared silica coated iron oxide nanoparticles delivering immunosuppressive drugs.•We examine drug releasing and immunomodulatory effects of nanoparticles.•Drug deliverin...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-06, Vol.142, p.290-296
Hauptverfasser:	Hwang, Jangsun, Lee, Eunwon, Kim, Jieun, Seo, Youngmin, Lee, Kwan Hong, Hong, Jong Wook, Gilad, Assaf A., Park, Hansoo, Choi, Jonghoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Contrast agents Cytokines Drug Carriers Drug Compounding Drug delivery Drug delivery systems Drug Liberation Drugs Ferric Compounds - chemistry Humans Hydrophobic and Hydrophilic Interactions Imaging Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Immunosuppressive drug Interleukin-2 - antagonists & inhibitors Interleukin-2 - biosynthesis Interleukin-2 - secretion Iron oxide nanoparticles Iron oxides Kinetics Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Magnetic resonance imaging Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - ultrastructure Mycophenolic acid Mycophenolic Acid - chemistry Mycophenolic Acid - pharmacology Nanoparticles Particle Size Phytohemagglutinins - pharmacology Primary Cell Culture Secretions Silicon Dioxide - chemistry Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - secretion
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