Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs
Polyethylene glycol hydrogels (PEG) have been used as slow release carrier for osteoinductive growth factors in order to achieve a retarded delivery. However, there have been concerns about negative effects on bone regeneration. This study aims to test whether PEG hydrogels themselves affect new bon...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2015-06, Vol.26 (6), p.194-7, Article 194 |
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| creator | Brockmeyer, Phillipp Kramer, Katharina Krohn, Sebastian Kauffmann, Philipp Mauth, Corinna Dard, Michel Schliephake, Henning Gruber, Rudolf Matthias |
| description | Polyethylene glycol hydrogels (PEG) have been used as slow release carrier for osteoinductive growth factors in order to achieve a retarded delivery. However, there have been concerns about negative effects on bone regeneration. This study aims to test whether PEG hydrogels themselves affect new bone formation (NBF), when used as a carrier during mandibular augmentation procedures. In a randomized split-mouth design, bilateral mandibular bone defects were surgically created in 12 Goettingen minipigs, and subsequently augmented, using PEG hydrogel on one side of the mandible. The contralateral sides, without PEG, served as controls. After 4 and 12 weeks, bone formation was evaluated in six animals each. A comparison of the data, using a three-way analysis of variance (ANOVA), revealed a significant effect of the healing time and the region of the graft on the distribution and enhancement of NBF (
P
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| doi_str_mv | 10.1007/s10856-015-5526-z |
| format | Article |
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P
< .0001, respectively). Although a 0.3 % (95 %-CI [−5.5; 4.8]) lower volume density of newly formed bone could be observed over all PEG hydrogel sections, in contrast to the contralateral controls, the analysis revealed no clinically significant effects of the PEG hydrogel treatment on the total level (
P
= 0.90), and the distribution of NBF (
P
= 0.54). In conclusion, PEG hydrogels do not affect NBF when used as a carrier for osteoinductive growth factors during mandibular augmentation procedures.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-015-5526-z</identifier><identifier>PMID: 26032116</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorbable Implants ; Analysis of variance ; Animals ; Augmentation ; Biomaterials ; Biomaterials Synthesis and Characterization ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone Regeneration ; Bone Substitutes - chemistry ; Bones ; Carriers ; Ceramics ; Chemistry and Materials Science ; Composites ; Female ; Formations ; Glass ; Hydrogels ; Mandible - anatomy & histology ; Mandible - physiology ; Mandible - surgery ; Materials Science ; Materials Testing ; Natural Materials ; Osteogenesis ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Surfaces and Interfaces ; Swine ; Swine, Miniature ; Thin Films</subject><ispartof>Journal of materials science. Materials in medicine, 2015-06, Vol.26 (6), p.194-7, Article 194</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-a06ba5e4e8f6fea9c1e1fa8dd4238fb3b7ebc2a18b9bda0512241f5c5f67d2813</citedby><cites>FETCH-LOGICAL-c438t-a06ba5e4e8f6fea9c1e1fa8dd4238fb3b7ebc2a18b9bda0512241f5c5f67d2813</cites><orcidid>0000-0003-3694-2828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-015-5526-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-015-5526-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26032116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brockmeyer, Phillipp</creatorcontrib><creatorcontrib>Kramer, Katharina</creatorcontrib><creatorcontrib>Krohn, Sebastian</creatorcontrib><creatorcontrib>Kauffmann, Philipp</creatorcontrib><creatorcontrib>Mauth, Corinna</creatorcontrib><creatorcontrib>Dard, Michel</creatorcontrib><creatorcontrib>Schliephake, Henning</creatorcontrib><creatorcontrib>Gruber, Rudolf Matthias</creatorcontrib><title>Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Polyethylene glycol hydrogels (PEG) have been used as slow release carrier for osteoinductive growth factors in order to achieve a retarded delivery. However, there have been concerns about negative effects on bone regeneration. This study aims to test whether PEG hydrogels themselves affect new bone formation (NBF), when used as a carrier during mandibular augmentation procedures. In a randomized split-mouth design, bilateral mandibular bone defects were surgically created in 12 Goettingen minipigs, and subsequently augmented, using PEG hydrogel on one side of the mandible. The contralateral sides, without PEG, served as controls. After 4 and 12 weeks, bone formation was evaluated in six animals each. A comparison of the data, using a three-way analysis of variance (ANOVA), revealed a significant effect of the healing time and the region of the graft on the distribution and enhancement of NBF (
P
< .0001, respectively). Although a 0.3 % (95 %-CI [−5.5; 4.8]) lower volume density of newly formed bone could be observed over all PEG hydrogel sections, in contrast to the contralateral controls, the analysis revealed no clinically significant effects of the PEG hydrogel treatment on the total level (
P
= 0.90), and the distribution of NBF (
P
= 0.54). In conclusion, PEG hydrogels do not affect NBF when used as a carrier for osteoinductive growth factors during mandibular augmentation procedures.</description><subject>Absorbable Implants</subject><subject>Analysis of variance</subject><subject>Animals</subject><subject>Augmentation</subject><subject>Biomaterials</subject><subject>Biomaterials Synthesis and Characterization</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bone Regeneration</subject><subject>Bone Substitutes - chemistry</subject><subject>Bones</subject><subject>Carriers</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Female</subject><subject>Formations</subject><subject>Glass</subject><subject>Hydrogels</subject><subject>Mandible - anatomy & histology</subject><subject>Mandible - physiology</subject><subject>Mandible - surgery</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Natural Materials</subject><subject>Osteogenesis</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymer Sciences</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Surfaces and Interfaces</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Thin 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brockmeyer, Phillipp</au><au>Kramer, Katharina</au><au>Krohn, Sebastian</au><au>Kauffmann, Philipp</au><au>Mauth, Corinna</au><au>Dard, Michel</au><au>Schliephake, Henning</au><au>Gruber, Rudolf Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>26</volume><issue>6</issue><spage>194</spage><epage>7</epage><pages>194-7</pages><artnum>194</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Polyethylene glycol hydrogels (PEG) have been used as slow release carrier for osteoinductive growth factors in order to achieve a retarded delivery. However, there have been concerns about negative effects on bone regeneration. This study aims to test whether PEG hydrogels themselves affect new bone formation (NBF), when used as a carrier during mandibular augmentation procedures. In a randomized split-mouth design, bilateral mandibular bone defects were surgically created in 12 Goettingen minipigs, and subsequently augmented, using PEG hydrogel on one side of the mandible. The contralateral sides, without PEG, served as controls. After 4 and 12 weeks, bone formation was evaluated in six animals each. A comparison of the data, using a three-way analysis of variance (ANOVA), revealed a significant effect of the healing time and the region of the graft on the distribution and enhancement of NBF (
P
< .0001, respectively). Although a 0.3 % (95 %-CI [−5.5; 4.8]) lower volume density of newly formed bone could be observed over all PEG hydrogel sections, in contrast to the contralateral controls, the analysis revealed no clinically significant effects of the PEG hydrogel treatment on the total level (
P
= 0.90), and the distribution of NBF (
P
= 0.54). In conclusion, PEG hydrogels do not affect NBF when used as a carrier for osteoinductive growth factors during mandibular augmentation procedures.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26032116</pmid><doi>10.1007/s10856-015-5526-z</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3694-2828</orcidid></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2015-06, Vol.26 (6), p.194-7, Article 194 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Absorbable Implants Analysis of variance Animals Augmentation Biomaterials Biomaterials Synthesis and Characterization Biomedical Engineering and Bioengineering Biomedical materials Bone Regeneration Bone Substitutes - chemistry Bones Carriers Ceramics Chemistry and Materials Science Composites Female Formations Glass Hydrogels Mandible - anatomy & histology Mandible - physiology Mandible - surgery Materials Science Materials Testing Natural Materials Osteogenesis Polyethylene glycol Polyethylene Glycols - chemistry Polymer Sciences Regenerative Medicine/Tissue Engineering Surfaces and Interfaces Swine Swine, Miniature Thin Films |
| title | Influence of synthetic polyethylene glycol hydrogels on new bone formation during mandibular augmentation procedures in Goettingen minipigs |
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