Pathogen-Mimicking Polymeric Nanoparticles based on Dopamine Polymerization as Vaccines Adjuvants Induce Robust Humoral and Cellular Immune Responses

Aiming to enhance the immunogenicity of subunit vaccines, a novel antigen delivery and adjuvant system based on dopamine polymerization on the surface of poly(d,l‐lactic‐glycolic‐acid) nanoparticles (NPs) with multiple mechanisms of immunity enhancement is developed. The mussel‐inspired biomimetic p...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-04, Vol.12 (13), p.1744-1757
Hauptverfasser:	Liu, Qi, Jia, Jilei, Yang, Tingyuan, Fan, Qingze, Wang, Lianyan, Ma, Guanghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - pharmacology Animals Antigens Cell Differentiation - drug effects Cell Proliferation - drug effects Cellular Chemokines - genetics Chemokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Dopamine Dopamine - chemistry dopamine polymerization Drug delivery systems Gene Expression Profiling Hepatitis B virus Immunity, Cellular - drug effects Immunity, Humoral - drug effects Immunization Indoles - chemistry Injections Kinetics Lactic Acid - chemistry Mice, Inbred BALB C Nanoparticles Nanoparticles - chemistry Nanotechnology Oligodeoxyribonucleotides - metabolism Particle Size pathogen-mimicking Polyglycolic Acid - chemistry polymeric nanoparticles Polymerization Polymers - chemistry Spleen - cytology Static Electricity surface modification T-Lymphocytes - immunology vaccine delivery and adjuvant systems Vaccines Vaccines - immunology
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