Production of a therapeutic protein by fusing it with two fragments of the carboxyl-terminal peptide of human chorionic gonadotropin β-subunit in Pichia pastoris

Objective To produce a therapeutic protein (endostatin) by fusion with two fragments of the carboxyl-terminal peptide (CTP) of the human chorionic gonadotropin β-subunit in Pichia pastoris . Results Two CTP sequences were fused to the C -terminal of human endostatin, and the fusion protein (endo-CTP...

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Veröffentlicht in:	Biotechnology letters 2016-05, Vol.38 (5), p.801-807
Hauptverfasser:	Wang, Baolong, Wang, Xin, Wayne, Chris, Wang, Xiangxiang, Han, Lei, Ye, Li, Zhao, Qun, Jiang, Guixiang, Feng, Meiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Applied Microbiology Biochemistry Biomedical and Life Sciences Biotechnology Cell Proliferation - drug effects Chorionic Gonadotropin - genetics Chorionic Gonadotropin - metabolism Endostatins - genetics Endostatins - metabolism Endostatins - pharmacokinetics Endothelial cells Endothelial Cells - drug effects Endothelial Cells - physiology Fragments Half-Life Human Inhibitory Concentration 50 Life Sciences Microbiology Migration Original Research Paper Peptides Pichia - genetics Pichia - metabolism Pichia pastoris Protein Subunits - genetics Protein Subunits - metabolism Proteins Rats, Sprague-Dawley Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism
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