Measurement of NK activity by the microcytotoxicity assay (MCA): a new application for an old assay

Natural killer (NK) cells are spontaneously cytotoxic immune effector cells with the ability to selectively destroy tumor cells without harming normal cells. To perform this function, NK cells utilize two main cytotoxicity pathways, the well known perforin/granzyme-mediated secretory/necrotic killin...

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Veröffentlicht in:	Journal of immunological methods 2001-07, Vol.253 (1), p.69-81
Hauptverfasser:	Wahlberg, Brendon J, Burholt, Dennis R, Kornblith, Paul, Richards, Thomas J, Bruffsky, Adams, Herberman, Ronald B, Vujanovic, Nikola L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Apoptosis Biological and medical sciences Breast Neoplasms - immunology Cell death Cell necrosis Chromium Radioisotopes Cytotoxicity assay Cytotoxicity Tests, Immunologic - methods Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Killer Cells, Natural - immunology Kinetics Leukocytes, Mononuclear - immunology Medical sciences Microbiology Molecular immunology Necrosis NK cells Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Techniques Tumor Cells, Cultured
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